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1.8.4.2: protein-disulfide reductase (glutathione)

This is an abbreviated version!
For detailed information about protein-disulfide reductase (glutathione), go to the full flat file.

Word Map on EC 1.8.4.2

Reaction

2 glutathione +

protein-disulfide
=
glutathione-disulfide
 +
protein-dithiol

Synonyms

BbdC, BdbD, C1orf31, CatA protein, ccdA associated thiol-disulfide oxidoreductase, COA6, DcbA, desulfothioredoxin, DIP1880, disulfide bond-forming thiol-disulfide oxidoreductase, disulphide interchange enzyme, DsbA, DsbA1, DsbA2, Dtrx, ERp57, GIT, glutathione-insulin transhydrogenase, glutathione-protein disulfide oxidoreductase, GRX1, GRX2, GRX3, GRX5, GRX6, GrxS12, GSH-dependent protein disulfide oxidoreductase, GSH-insulin transhydrogenase, HP_0231, insulin reductase, mcrophage migration inhibitory factor-2, MdbA, MdbACm, membrane-bound thiol-disulfide oxidoreductase, Mif-2, More, protein disulfide reductase (glutathione), protein disulfide transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, RCAP_rcc01743, reductase, protein disulfide (glutathione), ResA, SdbA, SGO_2006, SpyM18_2037, StoA, Streptococcus disulfide bond protein A, TDOR, thiol disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol-protein disulphide oxidoreductase, thiol:disulfide oxidoreductase, thiol:protein-disulfide oxidoreductase, WhiB1, WhiB1/Rv3219, YkuV, YMR244C-A

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.2 protein-disulfide reductase (glutathione)

Disease

topprint

Disease on EC 1.8.4.2 - protein-disulfide reductase (glutathione)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Burkitt Lymphoma
Multiprotein complexes present at the MIF motifs flanking the promoter of the human c-myc gene.
Cardiovascular Diseases
MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics.
Diabetic Nephropathies
TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.
Endotoxemia
Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia.
Hyperinsulinism
Insulin degradation. XVIII. On the regulation of glutathione-insulin transhydrogenase in the hyperglycemic obese (ob/ob) mouse.
Hypersensitivity
Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease.
Insulin Resistance
Serum insulin concentration, insulin release and degradation, glucose tolerance and in vivo insulin sensitivity in cholesterol-fed rats.
Insulinoma
Insulin degradation in insulinoma: evidence for the occurrence of an inactive form of glutathione-insulin transhydrogenase and for the absence of insulin A and B chains degrading protease(s).
Lysosomal Storage Diseases
Inhibition of CatA: an emerging strategy for the treatment of heart failure.
Obesity
Insulin degradation. XVIII. On the regulation of glutathione-insulin transhydrogenase in the hyperglycemic obese (ob/ob) mouse.
Pneumonia
Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients.
Renal Insufficiency, Chronic
Elevated MIF-2 levels predict mortality in critically ill patients.
Sepsis
Elevated MIF-2 levels predict mortality in critically ill patients.
Tuberculosis
Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase.
Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.
Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide sensitive iron-sulphur cluster.
Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2.
Redox biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide.
Regulation of the expression of whiB1 in Mycobacterium tuberculosis: role of cAMP receptor protein.
Structural basis of non-canonical transcriptional regulation by the ?A-bound iron-sulfur protein WhiB1 in M. tuberculosis.
Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.
Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.