1.8.4.14: L-methionine (R)-S-oxide reductase
This is an abbreviated version!
For detailed information about L-methionine (R)-S-oxide reductase, go to the full flat file.
Word Map on EC 1.8.4.14
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1.8.4.14
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methionine-r-sulfoxide
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reductases
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cys
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msrbs
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lifespan
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unicellular
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diastereomers
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sulfenic
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thiol-dependent
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aureus
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glutaredoxin
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protein-based
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trx
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selenocysteine
- 1.8.4.14
- methionine-r-sulfoxide
- reductases
- cys
-
msrbs
-
lifespan
-
unicellular
-
diastereomers
-
sulfenic
-
thiol-dependent
- aureus
- glutaredoxin
-
protein-based
- trx
- selenocysteine
Reaction
Synonyms
EC 1.8.4.5, fRMsr, methionine sulfoxide reductase, methionine-R-sulfoxide reductase, NMV_2074, TafRMsr
ECTree
1.8.4.14 L-methionine (R)-S-oxide reductaseAdvanced search results
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Engineering on EC 1.8.4.14 - L-methionine (R)-S-oxide reductase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C84A/C94A/C136A
about 35% of the catalytic efficiency of wild-type
C94A/C136A
about 35% of the catalytic efficiency of wild-type
C15S
C60S
C84S
C15S
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mutant exhibits apparent activity. The kcat and Km values of the mutant enzyme are similar to those of wild type, showing that Cys15 is dispensable for catalysis
C15S
kcat and Km values of C15S are similar to those of wild type. Cells expressing the C15S mutant enzyme show similar growth to wild type-expressing cells
C60S
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mutant exhibits apparent activity. The kcat value is dramatically reduced in the C60S mutant (80fold lower), while the Km value does not significantly change compared to wild type
C60S
the kcat value is reduced in the C60S mutant (80fold lower), while the Km value does not significantly change compared to wild type. In cells expressing C60S, growth is not observed during a 3-day incubation but observed at a 7-day incubation
C84S
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no detectable activity. Cells expressing C84S do not grow in the Met-O medium at all
C84S
activity is not detectable. Cells expressing C84S do not grow in the methionione sulfoxide medium at all
