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1.8.2.2: thiosulfate dehydrogenase

This is an abbreviated version!
For detailed information about thiosulfate dehydrogenase, go to the full flat file.

Word Map on EC 1.8.2.2

Reaction

2 thiosulfate +

2 ferricytochrome c
=
tetrathionate
+ 2 ferrocytochrome c + 4 H+

Synonyms

AFE_0042, Alvin_0091, AvTsdA, C8J_0815, D0Y83_01395, di-heme TsdA, DIE28_04650, diheme cytochrome c TsdA, enzymes, thiosulfate-oxidizing, MpTsdBA, oxidase, thiosulfate, Tat pathway signal sequence domain protein, tetrathionate reductase, tetrathionate synthase, thiosulfate dehydrogenase, thiosulfate oxidase, thiosulfate-acceptor oxidoreductase, thiosulfate-oxidizing enzyme, TSD, TsdA

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.2 With a cytochrome as acceptor
                1.8.2.2 thiosulfate dehydrogenase

Inhibitors

Inhibitors on EC 1.8.2.2 - thiosulfate dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
17% inhibition at 5 mM
2,2'-bipyridine
-
1 mM, 22% residual activity
2,2'-bipyridyl
AsO2-
-
1 mM, 50% residual activity
azide
Cupferron
heterotrophic bacterium
-
strongly inhibits thiosulfate oxidation by A-50 extracts
cyanide
deoxycholate
-
-
diethyldicarbonate
-
-
diethyldithiocarbamate
heterotrophic bacterium
-
slightly inhibits
dithionate
-
18% inhibition at 1 mM, 15% inhibition at 0.1 mM and 0.01 mM
HgCl2
iodoacetate
-
1 mM, 51% residual activity
N-ethylmaleimide
Na2SeO3
Na2SeO4
-
51% inhibition at 5 mM
o-phenanthroline
-
1 mM, 12% residual activity
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
50% inhibition at 1 mM, 40% inhibition at 0.5 mM and 10% inhibition at 0.1 mM
SO42-
-
33% inhibition at 1 mM, 15% inhibition at 0.1 mM, 7% inhibition at 0.01 mM
Sodium azide
-
1 mM, 74% residual activity
sulfate
200 mM, about 60% reduction in activity
sulfite
2 mM, 1.6fold stimulation. Inhibitory at higher concentrations, almost complete inhibition at 10 mM
thiocyanate
-
slightly inhibits
thiosulfate
-
inhibitory above 0.75 mM
additional information
-
reagents selective for arginine, cysteine and tryptophane have no effect on enzyme activity
-