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1.8.1.8: protein-disulfide reductase

This is an abbreviated version!
For detailed information about protein-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.8

Reaction

protein-dithiol
+
NAD(P)+
=
protein-disulfide
 +
NAD(P)H
 +
H+

Synonyms

AhpF, disulfide reductase, EC 1.6.4.4, ERdj5, ERp16, glutaredoxin, HvTrxh2, insulin-glutathione transhydrogenase, LpdA, MA3736, MA_1658, MdrA, methanoredoxin, More, NAD(P)H:protein-disulfide oxidoreductase, NADH-linked disulfide reductase, panthethine 4'4-diphosphate-specific reductase, PDI reductase, PDO, PfPDO, PH1130 protein, PhDsb, protein disulfide isomerase reductase, protein disulfide oxidoreductase, protein disulfide reductase, protein-disulfide oxidoreductase, protein-disulfide reductase (NAD(P)H), reductase, protein disulfide, thiol-disulfide oxidoreductase, TON_0319, TTC0486, WhiB1, WhiB1/Rv3219

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.8 protein-disulfide reductase

KM Value

KM Value on EC 1.8.1.8 - protein-disulfide reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0016 - 0.011
2,6-dimethyl-1,4-benzoquinone
0.00039 - 0.0055
5-hydroxy-1,4-naphthoquinone
7.4
CoA-SS-CoA
-
-
4.1
coenzyme A
pH 6.8, 50°C
2.2
coenzyme M
pH 6.8, 50°C
8.9
glutathione disulfide
pH 6.8, 50°C
0.028 - 0.036
NADH
0.00044 - 0.002
NADPH
0.65
pantethine 4',4''-diphosphate
-
-
0.0054 - 0.018
thio-NAD+
additional information
additional information
-
steady-state kinetics, ping-pong kinetic mechanism with NAD(P)H and 2,6-dimethyl-1,4-benzoquinone or 5-hydroxy-1,4-naphthoquinone
-