1.8.1.6: cystine reductase

This is an abbreviated version!
For detailed information about cystine reductase, go to the full flat file.

Reaction

2 L-cysteine +

Synonyms

CydDC, CysR, cystine reductase (NADH), cystine reductase (NADH2), EC 1.6.4.1, L-cysteine:NAD+ oxidoreductase, L-cystine reductase, NADH-dependent cystine reductase, NADH2:L-cystine oxidoreductase, reductase, cystine, thioredoxin domain containing 17, thioredoxin-like 5, TRP14, TXNDC17, TXNL5

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.6 cystine reductase

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4	Activating Compound
4	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
7	Cofactor
40	Disease/ Diagnostics
4	General Information
12	Inhibitors
1	kcat/KM [mM/s]
5	KM Value [mM]
2	Localization
4	Natural Substrates/ Products (Substrates)
11	Organism
4	Pathway
1	pH Optimum
3	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reaction Type
11	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.8.1.6 - cystine reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

L-cystine + glutathione

L-cysteine + GSSG

Ulva intestinalis

-

-

667725

-

-

?

L-cystine + NADH + H+

2 L-cysteine + NAD+

2 entries

NADH + L-cystine

?

Histoplasma capsulatum

-

the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form

440354

-

-

?

NADH + L-cystine

NAD+ + L-cysteine

6 entries

NADH + L-cystine + H+

NAD+ + L-cysteine

2 entries

additional information

?

-

4 entries

L-cystine + NADH + H+

2 L-cysteine + NAD+

Escherichia coli

-

-

765683

-

-

?

L-cystine + NADH + H+

2 L-cysteine + NAD+

Homo sapiens

Q9BRA2

-

743682

-

-

?

NADH + L-cystine

NAD+ + L-cysteine

Candida albicans

-

-

440353

-

440353

?

NADH + L-cystine

NAD+ + L-cysteine

Histoplasma capsulatum

-

-

440354

-

440354

?

NADH + L-cystine

NAD+ + L-cysteine

Pisum sativum

-

-

440353

-

440353

?

NADH + L-cystine

NAD+ + L-cysteine

Saccharomyces cerevisiae

-

-

440353

-

440353

?

NADH + L-cystine

NAD+ + L-cysteine

Saccharomyces cerevisiae

-

-

440355

-

440355

?

NADH + L-cystine

NAD+ + L-cysteine

Saccharomyces cerevisiae

-

-

440356

-

440356

?

NADH + L-cystine + H+

NAD+ + L-cysteine

Acanthamoeba polyphaga

-

-

673491

-

-

?

NADH + L-cystine + H+

NAD+ + L-cysteine

Naegleria fowleri

-

-

673491

-

-

?

additional information

?

-

Homo sapiens

Q9BRA2

enzyme TRP14 not being able to reduce any classical protein disulfide substrates of thioredoxin 1, Trx1. Trx1-mediated L-cystine reduction is inefficient in the presence of other preferred Trx1 substrates whereas, conversely, TRP14 seems to be a more dedicated L-cystine reductase

743682

-

-

?

additional information

?

-

Homo sapiens

-

enzyme TRP14 not being able to reduce any classical protein disulfide substrates of thioredoxin 1, Trx1. Trx1-mediated L-cystine reduction is inefficient in the presence of other preferred Trx1 substrates whereas, conversely, TRP14 seems to be a more dedicated L-cystine reductase

743682

-

-

?

additional information

?

-

Homo sapiens

Q9BRA2

enzyme TRP14 has S-denitrosylase activity performing GSNO reduction with realease of NO, it is also active with L-CysSNO

743682

-

-

?

additional information

?

-

Homo sapiens

-

enzyme TRP14 has S-denitrosylase activity performing GSNO reduction with realease of NO, it is also active with L-CysSNO

743682

-

-

?