1.8.1.6: cystine reductase

This is an abbreviated version!
For detailed information about cystine reductase, go to the full flat file.

Word Map on EC 1.8.1.6

Reaction

2 L-cysteine +

NAD+
=
L-cystine
+
NADH
+
H+

Synonyms

CysR, cystine reductase (NADH), cystine reductase (NADH2), EC 1.6.4.1, L-cysteine:NAD+ oxidoreductase, L-cystine reductase, NADH-dependent cystine reductase, NADH2:L-cystine oxidoreductase, reductase, cystine, thioredoxin domain containing 17, thioredoxin-like 5, TRP14, TXNDC17, TXNL5

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.6 cystine reductase

Natural Substrates Products

Natural Substrates Products on EC 1.8.1.6 - cystine reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-cystine + NADH + H+
2 L-cysteine + NAD+
show the reaction diagram
-
-
-
?
NADH + L-cystine
?
show the reaction diagram
-
the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form
-
-
-
additional information
?
-
enzyme TRP14 not being able to reduce any classical protein disulfide substrates of thioredoxin 1, Trx1. Trx1-mediated L-cystine reduction is inefficient in the presence of other preferred Trx1 substrates whereas, conversely, TRP14 seems to be a more dedicated L-cystine reductase
-
-
-