1.8.1.6: cystine reductase

This is an abbreviated version!
For detailed information about cystine reductase, go to the full flat file.

Reaction

2 L-cysteine +

Synonyms

CydDC, CysR, cystine reductase (NADH), cystine reductase (NADH2), EC 1.6.4.1, L-cysteine:NAD+ oxidoreductase, L-cystine reductase, NADH-dependent cystine reductase, NADH2:L-cystine oxidoreductase, reductase, cystine, thioredoxin domain containing 17, thioredoxin-like 5, TRP14, TXNDC17, TXNL5

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.6 cystine reductase

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Results	in table
4	Activating Compound
4	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
7	Cofactor
40	Disease/ Diagnostics
4	General Information
12	Inhibitors
1	kcat/KM [mM/s]
5	KM Value [mM]
2	Localization
4	Natural Substrates/ Products (Substrates)
11	Organism
4	Pathway
1	pH Optimum
3	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reaction Type
11	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Disease

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Disease on EC 1.8.1.6 - cystine reductase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Bone Resorption

TRP14 inhibits osteoclast differentiation via its catalytic activity.

25002534

Colorectal Neoplasms

Retraction notice to "STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells" [GENE 584 (1) (2016) 75-82].

31901301

Colorectal Neoplasms

STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells.

26976343

Decompression Sickness

Dynorphin-phospholipid membrane interactions: role of phospholipid head-group and cholesterol.

8907503

Hypersensitivity

CydDC functions as a cytoplasmic cystine reductase to sensitize Escherichia coli to oxidative stress and aminoglycosides.

32900959

Hypersensitivity

Isogenic mutations in the Moraxella catarrhalis CydDC system display pleiotropic phenotypes and reveal the role of a palindrome sequence in its transcriptional regulation.

28647125

Infections

The CydDC Family of Transporters and Their Roles in Oxidase Assembly and Homeostasis.

26210105

Infections

The CydDC family of transporters.

31279084

Neoplasms

Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.

18579519

Neoplasms

Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.

14607843

Neoplasms

Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin-related protein 14-mediated autophagy.

28498513

Neoplasms

Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: Implication in the redox regulation of TNF-alpha signaling.

19628032

Neoplasms

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.

25607466

Neuroblastoma

Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin-related protein 14-mediated autophagy.

28498513

Ovarian Neoplasms

TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer.

31524236

Ovarian Neoplasms

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.

25607466

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