1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)

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For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.

Reaction

Synonyms

2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)

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Results	in table
6	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
13	Cofactor
4	Crystallization (Commentary)
2	General Information
4	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
16	PDB ID
1	pH Optimum
9	Protein Variants
2	Purification (Commentary)
3	Reaction
3	Reaction Type
13	Reference
2	Specific Activity [micromol/min/mg]
28	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)

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SYSTEMATIC NAME

IUBMB Comments

2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)

Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-sulfanylethane-1-sulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.