1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)
This is an abbreviated version!
For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.
Word Map on EC 1.8.1.5
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1.8.1.5
-
propylene
-
thioether
-
co2
-
acetone
-
xanthobacter
-
flavin
-
2-bromoethanesulfonate
-
dyad
-
co2-fixing
-
fad-containing
-
epoxypropane
-
epoxide
-
autotrophicus
-
phe-his
-
pka
-
electrophile
-
thioredoxins
-
his-glu
-
interchange
-
encapsulate
-
air-oxidized
- 1.8.1.5
- propylene
- thioether
- co2
- acetone
- xanthobacter
- flavin
- 2-bromoethanesulfonate
-
dyad
-
co2-fixing
-
fad-containing
- epoxypropane
- epoxide
- autotrophicus
-
phe-his
- pka
-
electrophile
- thioredoxins
- his-glu
-
interchange
-
encapsulate
-
air-oxidized
Reaction
Synonyms
2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC
ECTree
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Reference
Reference on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)
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Allen, J.R.; Clark, D.D.; Krum, J.G.; Ensign, S.A.
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation
Proc. Natl. Acad. Sci. USA
96
8432-8437
1999
Xanthobacter sp., Xanthobacter sp. Py2
Clark, D.D.; Allen, J.R.; Ensign, S.A.
Characterization of five catalytic activities associated with the NADPH:2-ketopropyl-coenzyme M [2-(2-ketopropylthio)ethanesulfonate] oxidoreductase/carboxylase of the Xanthobacter strain Py2 epoxide carboxylase system
Biochemistry
39
1294-1304
2000
Xanthobacter sp., Xanthobacter sp. Py2
Jang, S.B.; Jeong, M.S.; Clark, D.D.; Ensign, S.A.; Peters, J.W.
Crystallization and preliminary X-ray analysis of a NADPH 2-ketopropyl-coenzyme M oxidoreductase/carboxylase
Acta Crystallogr. Sect. D
57
445-447
2001
Xanthobacter sp.
Nocek, B.; Jang, S.B.; Jeong, M.S.; Clark, D.D.; Ensign, S.A.; Peters, J.W.
Structural basis for CO2 fixation by a novel member of the disulfide oxidoreductase family of enzymes, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase
Biochemistry
41
12907-12913
2002
Xanthobacter autotrophicus (Q56839)
Pandey, A.S.; Nocek, B.; Clark, D.D.; Ensign, S.A.; Peters, J.W.
Mechanistic implications of the structure of the mixed-disulfide intermediate of the disulfide oxidoreductase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase
Biochemistry
45
113-120
2006
Xanthobacter autotrophicus (Q56839)
Boyd, J.M.; Clark, D.D.; Kofoed, M.A.; Ensign, S.A.
Mechanism of inhibition of aliphatic epoxide carboxylation by the coenzyme M analog 2-bromoethanesulfonate
J. Biol. Chem.
285
25232-25242
2010
Xanthobacter autotrophicus
Pandey, A.S.; Mulder, D.W.; Ensign, S.A.; Peters, J.W.
Structural basis for carbon dioxide binding by 2-ketopropyl coenzyme M oxidoreductase/carboxylase
FEBS Lett.
585
459-464
2011
Xanthobacter autotrophicus (Q56839)
Kofoed, M.A.; Wampler, D.A.; Pandey, A.S.; Peters, J.W.; Ensign, S.A.
Roles of the redox-active disulfide and histidine residues forming a catalytic dyad in reactions catalyzed by 2-ketopropyl coenzyme M oxidoreductase/carboxylase
J. Bacteriol.
193
4904-4913
2011
Xanthobacter autotrophicus (Q56839)
Prussia, G.A.; Gauss, G.H.; Mus, F.; Conner, L.; DuBois, J.L.; Peters, J.W.
Substitution of a conserved catalytic dyad into 2-KPCC causes loss of carboxylation activity
FEBS Lett.
590
2991-2996
2016
Xanthobacter autotrophicus (Q56839)
Streit, B.R.; Mattice, J.R.; Prussia, G.A.; Peters, J.W.; DuBois, J.L.
The reactive form of a C-S bond-cleaving, CO2-fixing flavoenzyme
J. Biol. Chem.
294
5137-5145
2019
Xanthobacter autotrophicus (Q56839)
Prussia, G.A.; Shisler, K.A.; Zadvornyy, O.A.; Streit, B.R.; DuBois, J.L.; Peters, J.W.
The unique Phe-His dyad of 2-ketopropyl coenzyme M oxidoreductase/carboxylase selectively promotes carboxylation and S-C bond cleavage
J. Biol. Chem.
297
100961
2021
Xanthobacter autotrophicus (Q56839)
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