1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)

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For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.

Reaction

Synonyms

2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)

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Results	in table
6	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
13	Cofactor
4	Crystallization (Commentary)
2	General Information
4	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
16	PDB ID
1	pH Optimum
9	Protein Variants
2	Purification (Commentary)
3	Reaction
3	Reaction Type
13	Reference
2	Specific Activity [micromol/min/mg]
28	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

General Information

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General Information on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Xanthobacter autotrophicus

Q56839

the enzyme belongs to the disulfide oxidoreductase (DSOR) family of enzymes. The characteristic His-Glu catalytic dyad of the DSOR family is replaced in 2-ketopropyl coenzyme M oxidoreductase/carboxylase (2-KPCC) uniquely by the residues Phe-His, potentially to eliminate proton-donating groups at a key position in the active site. These differences in 2-KPCC are key in discriminating between carbon dioxide and protons as attacking electrophiles

742523

physiological function

Xanthobacter autotrophicus

Q56839

2-oxopropylcoenzyme M oxidoreductase/carboxylase (2-KPCC) catalyzes the reductive cleavage and carboxylation of 2-oxopropyl coenzyme M (2-KPC) to form acetoacetate and concomitantly regenerate CoM (2-mercaptoethanesulfonate)

742523