1.8.1.16: glutathione amide reductase

This is an abbreviated version!
For detailed information about glutathione amide reductase, go to the full flat file.

Reaction

2 glutathione amide +

NAD+
=
glutathione amide disulfide
+
NADH
+
H+

Synonyms

GAR, garB

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.16 glutathione amide reductase

Systematic Name

Systematic Name on EC 1.8.1.16 - glutathione amide reductase

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SYSTEMATIC NAME
IUBMB Comments
glutathione amide:NAD+ oxidoreductase
A dimeric flavoprotein (FAD). The enzyme restores glutathione amide disulfide, which is produced during the reduction of peroxide by EC 1.11.1.17 (glutathione amide-dependent peroxidase), back to glutathione amide (it catalyses the reaction in the opposite direction to that shown). The enzyme belongs to the family of flavoprotein disulfide oxidoreductases, but unlike other members of the family, which are specific for NADPH, it prefers NADH [1].