1.8.1.15: mycothione reductase

This is an abbreviated version!
For detailed information about mycothione reductase, go to the full flat file.

Reaction

2 mycothiol +

Synonyms

MSH disulfide reductase, MtMtr, MTR, mycothiol disulfide reductase, mycothiol disulphide reductase, mycothiol-disulfide reductase, mycothione disulphide reductase, mycothione reductase, NADPH-dependent mycothiol reductase, NADPH-dependent mycothione reductase

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.15 mycothione reductase

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Results	in table
840	AA Sequence
4	Application
8	Cloned(Commentary)
17	Cofactor
1	Expression
9	General Information
3	Inhibitors
9	kcat/KM [mM/s]
1	Ki Value [mM]
35	KM Value [mM]
5	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
233	Organism
1	Pathway
3	pH Optimum
7	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
22	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
57	Substrates and Products (Substrate)
12	Subunits
31	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
24	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.8.1.15 - mycothione reductase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-(5-bromo-2-methoxyphenyl)acrylonitrile

Mycobacterium tuberculosis

-

time-dependent inhibitor

701668

DMSO

Mycobacterium tuberculosis

-

in the presence of 4% (v/v) DMSO, Mycobacterium tubercolosis reductase activity is reduced by only 10%. It is recommended that the DMSO content in sets of inhibition assays should be kept at a constant with 4% (v/v) DMSO as the upper limit

701668

additional information

Mycobacterium tuberculosis

-

plant extracts from Alectra sessiliflora, Aloe plicatilis, Eucomis humilis, Eucomis vandermerwei, Euphorbia tirrucalli, Faurea saligna, Merwillia plumbea, Salvia africana-lutea, Sphedamnocarpus pruriens, Tarchonanthus camphorates, Typha capensis, Typha minima, and Withania somnifera show inhibitory activities against the enzyme exhibiting IC50 values of 0.1678, 0.9934, 0.3206, 0.1347, 0.2391, 0.042, 0.2361, 0.1023, 0.0615, 0.1329, 0.0538, 0.0479, and 0.1624 mg/ml, respectively

765839

-