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1.8.1.15: mycothione reductase

This is an abbreviated version!
For detailed information about mycothione reductase, go to the full flat file.

Word Map on EC 1.8.1.15

Reaction

2 mycothiol +

NAD(P)+
=
mycothione
 +
NAD(P)H
 +
H+

Synonyms

MSH disulfide reductase, MtMtr, MTR, mycothiol disulfide reductase, mycothiol disulphide reductase, mycothiol-disulfide reductase, mycothione disulphide reductase, mycothione reductase, NADPH-dependent mycothiol reductase, NADPH-dependent mycothione reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.15 mycothione reductase

Engineering

Engineering on EC 1.8.1.15 - mycothione reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D158A/Y159A
-
the mutant exhibits enhanced NADPH oxidation rate compared to the wild type enzyme
S144A
-
the mutant exhibits enhanced NADPH oxidation rate compared to the wild type enzyme
S268A
-
the mutant exhibits enhanced NADPH oxidation rate compared to the wild type enzyme
D158A/Y159A
-
the mutant exhibits enhanced NADPH oxidation rate compared to the wild type enzyme
-
S144A
-
the mutant exhibits enhanced NADPH oxidation rate compared to the wild type enzyme
-
S268A
-
the mutant exhibits enhanced NADPH oxidation rate compared to the wild type enzyme
-
additional information
-
overexpression of mycothiol disulfide reductase enhances Corynebacterium glutamicum robustness by modulating cellular redox homeostasis and antioxidant proteins under oxidative stress. Overexpression of Mtr causes a marked increase in the ratio of reduced to oxidized mycothiol (MSH:MSSM), and significantly enhances the activities of a variety of antioxidant enzymes, including mycothiol peroxidase (MPx), mycoredoxin 1 (Mrx1), thioredoxin 1 (Trx1), and methionine sulfoxide reductase A (MsrA). The mycothione levels of enzyme expressing cells are lower than those of untransfectde cells under H2O2, ciprofloxacin, CdCl2, N-ethylmaleimide, iodoacetamide, methylglyoxal, and 1-chloro-2,4-dinitrobenzene stresses, no significant difference in MSH or MSSM levels when both cells are exposed to formaldehyde and rifamycin SV