1.8.1.12: trypanothione-disulfide reductase
This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.12
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1.8.1.12
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trypanosoma
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leishmania
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cruzi
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chagas
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trypanosomatids
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leishmaniasis
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brucei
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trypanocidal
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antileishmanial
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donovani
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promastigotes
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trypanosomiasis
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infantum
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amastigotes
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fasciculata
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antitrypanosomal
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crithidia
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antiparasitic
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flavoenzyme
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phenothiazine
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medicine
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epimastigotes
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nifurtimox
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amazonensis
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antiprotozoal
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trypomastigotes
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tryparedoxin
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kinetoplastida
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leishmanicidal
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congolense
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rhodesiense
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miltefosine
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antimonial
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ts2
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n1,n8-bisglutathionylspermidine
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benznidazole
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clomipramine
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glutathionylspermidine
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antichagasic
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thioridazine
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ovothiols
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nitrofuran
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trypanothione-dependent
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pharmacology
- 1.8.1.12
- trypanosoma
- leishmania
- cruzi
- chagas
-
trypanosomatids
- leishmaniasis
- brucei
-
trypanocidal
-
antileishmanial
- donovani
- promastigotes
- trypanosomiasis
- infantum
- amastigotes
- fasciculata
-
antitrypanosomal
- crithidia
-
antiparasitic
-
flavoenzyme
- phenothiazine
- medicine
- epimastigotes
- nifurtimox
- amazonensis
-
antiprotozoal
- trypomastigotes
- tryparedoxin
- kinetoplastida
-
leishmanicidal
- congolense
- rhodesiense
- miltefosine
-
antimonial
- ts2
-
n1,n8-bisglutathionylspermidine
- benznidazole
- clomipramine
- glutathionylspermidine
-
antichagasic
- thioridazine
-
ovothiols
-
nitrofuran
-
trypanothione-dependent
- pharmacology
Reaction
Synonyms
EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR
ECTree
1.8.1.12 trypanothione-disulfide reductaseAdvanced search results
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results (KM Value
KM Value on EC 1.8.1.12 - trypanothione-disulfide reductase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.448
4-aminobutyryl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
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-
0.3
5,5'-dithiobis(N-[3-(4-methylpiperazin-1-yl)propyl]-2-nitrobenzamide)
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recombinant enzyme
0.035
5,5'-dithiobis(N-[3-(dimethylamino)propyl]-2-nitrobenzamide)
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recombinant enzyme
0.693
L-beta-aspartyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
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-
0.225
L-gamma-glutamyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
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-
0.052
N-benzyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
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-
0.251
tert-butyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
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0.022 - 0.275
glutathionylspermidine disulfide
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dependent on buffer system
0.0015
trypanothione disulfide
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apparent value, in the presence of 0.05 mM DTNB and 0.15 mM NADPH, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) BSA, and 0.05% (v/v) Tween 20, pH 7.5, at 22°C
0.0206
trypanothione disulfide
wild type enzyme, pH and temperature not specified in the publication
0.023
trypanothione disulfide
in the absence of 4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine, at 20°C, pH not specified in the publication
0.0253
trypanothione disulfide
mutant enzyme Q439A, pH and temperature not specified in the publication
0.0493
trypanothione disulfide
mutant enzyme W81A, pH and temperature not specified in the publication
0.053
trypanothione disulfide
in the presence of 0.01 mM 4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine, at 20°C, pH not specified in the publication
0.075
trypanothione disulfide
in the presence of 0.03 mM 4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine, at 20°C, pH not specified in the publication
0.1922
trypanothione disulfide
mutant enzyme E436A, pH and temperature not specified in the publication
0.5
trypanothione disulfide
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recombinant glutathione-trypanothione reductase-like enzyme
additional information
additional information
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Km dependent on assay conditions
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additional information
additional information
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Km of several trypanothione disulfide derivatives, e.g. N1-monoglutathionylspermidine, mixed disulfide of N1-monoglutathionylspermidine and glutathione
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