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1.8.1.12: trypanothione-disulfide reductase

This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.12

Reaction

trypanothione
+
NADP+
=
trypanothione disulfide
+
NADPH
+
H+

Synonyms

EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.12 trypanothione-disulfide reductase

General Stability

General Stability on EC 1.8.1.12 - trypanothione-disulfide reductase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
loss of 39% activity after incubation with NADPH at 25°C
-
the enzyme retains 76.02% and 41.17% activity in the presence of 2 M urea after 1 and 24 h, respectively. The enzyme regains activity up to 54.91% after denaturation in 8 M urea. The enzyme is active even after 24 h of guanidine hydrochloride treatment and contains 74.67% and 13.33% activity in 2 M after 1 and 24 h, respectively. Once denatured with 6 M guanidine hydrochloride, the protein regains 45.73% once guanidine hydrochloride is dialyzed
-
the loss of activity at lower denaturant (urea) concentrations is not coincided by dimer dissociation or structural unfolding
-