1.8.1.12: trypanothione-disulfide reductase
This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.12
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1.8.1.12
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trypanosoma
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leishmania
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cruzi
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chagas
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trypanosomatids
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leishmaniasis
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brucei
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trypanocidal
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antileishmanial
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donovani
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promastigotes
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trypanosomiasis
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infantum
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amastigotes
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fasciculata
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antitrypanosomal
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crithidia
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antiparasitic
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flavoenzyme
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phenothiazine
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medicine
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epimastigotes
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nifurtimox
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amazonensis
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antiprotozoal
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trypomastigotes
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tryparedoxin
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kinetoplastida
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leishmanicidal
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congolense
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rhodesiense
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miltefosine
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antimonial
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ts2
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n1,n8-bisglutathionylspermidine
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benznidazole
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clomipramine
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glutathionylspermidine
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antichagasic
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thioridazine
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ovothiols
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nitrofuran
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trypanothione-dependent
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pharmacology
- 1.8.1.12
- trypanosoma
- leishmania
- cruzi
- chagas
-
trypanosomatids
- leishmaniasis
- brucei
-
trypanocidal
-
antileishmanial
- donovani
- promastigotes
- trypanosomiasis
- infantum
- amastigotes
- fasciculata
-
antitrypanosomal
- crithidia
-
antiparasitic
-
flavoenzyme
- phenothiazine
- medicine
- epimastigotes
- nifurtimox
- amazonensis
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antiprotozoal
- trypomastigotes
- tryparedoxin
- kinetoplastida
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leishmanicidal
- congolense
- rhodesiense
- miltefosine
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antimonial
- ts2
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n1,n8-bisglutathionylspermidine
- benznidazole
- clomipramine
- glutathionylspermidine
-
antichagasic
- thioridazine
-
ovothiols
-
nitrofuran
-
trypanothione-dependent
- pharmacology
Reaction
Synonyms
EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR
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General Information
General Information on EC 1.8.1.12 - trypanothione-disulfide reductase
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drug target
physiological function
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a promising target for the development of new chemotherapeutics to treat leishmaniasis and Chagas disease. The enzyme is a specific protein in Trypanosomatidae family and is used by the parasite as a strategy for drug resistance. The enzyme is absent in human
drug target
the enzyme fulfills most of the more relevant requirements to be an interesting drug target because it is essential for parasite survival, druggable, and absent in the host, where it is replaced by glutathione reductase
drug target
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the enzyme is a promising targets for the development of drugs selective against parasites of the family of trypanosomatids
drug target
the enzyme is a promising targets for the development of drugs selective against parasites of the family of trypanosomatids
drug target
the potent biomolecules 3-methoxycarpachromene and masticadienonic acid could be an effective strategy to solve antimony-resistant strains and represent drug candidates as anti-Trypanosomatidae species drugs
drug target
trypanothione (N1,N8-bis(glutathyonil)spermidine) and trypanothione reductase, which are rather unique to trypanosomes and completely absent in mammalian cells
drug target
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the enzyme is a promising targets for the development of drugs selective against parasites of the family of trypanosomatids
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the enzyme is essential for parasite survival
physiological function
glucose-6-phosphate dehydrogenase and trypanothione reductase interaction protects Leishmania donovani from metalloid mediated oxidative stress
physiological function
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the enzyme is an essential component of the antioxidant defenses in trypanosomatid parasites
physiological function
the enzyme plays a central role in the metabolic pathway of the parasite
physiological function
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trypanosomatids possess a unique redox metabolism based on the dithiol trypanothione and the enzyme trypanothione reductase (TR) that differs distinctively from the glutathione and glutathione reductase-based metabolism in mammals
physiological function
trypanosomatids possess a unique redox metabolism based on the dithiol trypanothione and the enzyme trypanothione reductase (TR) that differs distinctively from the glutathione and glutathione reductase-based metabolism in mammals
physiological function
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the enzyme is essential for parasite survival
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physiological function
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trypanosomatids possess a unique redox metabolism based on the dithiol trypanothione and the enzyme trypanothione reductase (TR) that differs distinctively from the glutathione and glutathione reductase-based metabolism in mammals
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