1.7.3.3: factor-independent urate hydroxylase

This is an abbreviated version!
For detailed information about factor-independent urate hydroxylase, go to the full flat file.

Word Map on EC 1.7.3.3

Reaction

Urate
+
O2
+
H2O
=
5-hydroxyisourate
+
H2O2

Synonyms

AaUO, AgUOX, ELITEK, Fasturtec, N-35, Nodule specific uricase, Nodulin 35, Nodulin 35 homolog, Non-symbiotic uricase, oxidase, urate, Rasburicase, Uaz, Uox, Urate oxidase, urate oxidoreductase, UriA, uric acid oxidase, uricase, uricase II, Uricoenzyme, Uricozyme

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.3 With oxygen as acceptor
                1.7.3.3 factor-independent urate hydroxylase

pH Range

pH Range on EC 1.7.3.3 - factor-independent urate hydroxylase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6
JX083378
more than 80% of maximum activity
6.5 - 9.5
-
free uricase shows at least 50% relative activity between pH 6.5 and 9.5, around pH 7.5, free uricase remains 81.16% of its maximum activity, while the uricase loaded in the lipid vesicles remains almost the same high activity (178.26%) as its optimum activity (179.72%)
6.5 - 11
-
pH 6.5: about 40% of maximal activity, pH 10.0: about 50% of maximal activity
7 - 11
-
pH 7: about 50% of activity maximum, pH 11: about 40% of activity maximum
7.4 - 9.6
-
50% of activity maximum at pH 7.4 and pH 9.6, free enzyme
7.5 - 8.5
-
-
8 - 10.2
-
pH 8.0: about 35% of activity maximum, pH 10.2: about 55% of activity maximum
8 - 11
-
50% of activity maximum at pH 8 and pH 11, immobilized enzyme
8.5 - 10.5
-
50% of activity maximum at pH 8.5 and pH 10.5
8.6 - 9.5
-
-
9
JX083378
more than 80% of maximum activity