1.7.3.3: factor-independent urate hydroxylase

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For detailed information about factor-independent urate hydroxylase, go to the full flat file.

Word Map on EC 1.7.3.3

1.7.3.3

hyperuricemia

peroxisomal

xanthine

allopurinol

gout

purine

catalase

allantoin

biosensors

electrode

hematologic

creatinine

oxonic

febuxostat

allantoinase

hyperkalemia

hypoxanthine

prophylaxis

flavus

hyperphosphatemia

urate-lowering

ureide

methemoglobinemia

pegylated

amperometric

uricosuric

hypocalcemia

tophi

benzbromarone

hominoid

phosphotungstate

microbodies

hypouricemic

probenecid

utilis

pimecrolimus

pharmacology

medicine

analysis

synthesis

weight-based

nodule-specific

miocene

drug development

Reaction

Synonyms

AaUO, AgUOX, dHU-wPU, ELITEK, Fasturtec, MVSM, N-35, Nodule specific uricase, Nodulin 35, Nodulin 35 homolog, Non-symbiotic uricase, oxidase, urate, Pucl, Rasburicase, Uaz, Uox, Urate oxidase, urate oxidoreductase, UriA, uric acid oxidase, uricase, uricase II, Uricoenzyme, Uricozyme

ECTree

1 Oxidoreductases

1.7 Acting on other nitrogenous compounds as donors

1.7.3 With oxygen as acceptor

1.7.3.3 factor-independent urate hydroxylase

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Results	in table
12	Activating Compound
6578	AA Sequence
36	Application
1	CAS Registry Number
52	Cloned(Commentary)
5	Cofactor
18	Crystallization (Commentary)
2480	Disease/ Diagnostics
12	Expression
1	General Information
34	General Stability
227	Inhibitors
16	kcat/KM [mM/s]
15	Ki Value [mM]
73	KM Value [mM]
39	Localization
41	Metals/Ions
72	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
185	Organism
1	Oxidation Stability
7	Pathway
218	PDB ID
45	pH Optimum
19	pH Range
19	pH Stability
8	pI Value
49	Protein Variants
55	Purification (Commentary)
3	Reaction
11	Reaction Type
182	Reference
74	Source Tissue
91	Specific Activity [micromol/min/mg]
18	Storage Stability
160	Substrates and Products (Substrate)
61	Subunits
117	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
11	Temperature Range [°C]
37	Temperature Stability [°C]
20	Turnover Number [1/s]

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General Information on EC 1.7.3.3 - factor-independent urate hydroxylase

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physiological function

Mammalia

ancestral uricases have steadily decreased in activity since the last common ancestor of mammals gave rise to descendent primate lineages. This progressive decrease is correlated with physiological function and (potential) adaptation. Analysis of the 3D distribution of amino acid replacements as they accumulated during evolutionary history

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