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1.7.2.1: nitrite reductase (NO-forming)

This is an abbreviated version!
For detailed information about nitrite reductase (NO-forming), go to the full flat file.

Word Map on EC 1.7.2.1

Reaction

nitric oxide
+
H2O
+
ferricytochrome c
=
nitrite
+
ferrocytochrome c
+ 2 H+

Synonyms

AcNIR, AfNiR, AniA, AxNiR, BRAO375_2740002, C551-O2 oxidoreductase, cd1 nitrite reductase, cd1NiR, cNOR, copper-containing dissimilatory nitrite reductase, copper-containing nitrite reductase, Cu-NIR, Cu-NirK, CuNIR, cytochrome c-551:O2, NO2- oxidoreductase, cytochrome cd, cytochrome cd1 nitrite reductase, cytochrome oxidase, dissimilatory nitrite reductase, dissimilatory nitrite reductase cytochrome cd1, EC 1.6.6.5, EC 1.7.99.3, EC 1.9.3.2, GK0767, GtNiR, HdNIR, hemoglobin, HydNIR, HYPDE_25578, KSU1_D0929, mARC1, mARC2, mitochondrial amidoxime reducing component, MRA2164, NiR, NiR-Pa, NirK, NirS, nitrite reductase, oxidase, Pseudomonas cytochrome, PaNiR, PNR, Pseudomonas cytochrome oxidase, PsNiR, reductase, nitrite (cytochrome), Rpic_4015, S58_68210

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.2 With a cytochrome as acceptor
                1.7.2.1 nitrite reductase (NO-forming)

Natural Substrates Products

Natural Substrates Products on EC 1.7.2.1 - nitrite reductase (NO-forming)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ferrocytochrome c-551 + O2
ferricytochrome c-551 + H2O
show the reaction diagram
-
-
-
?
nitric oxide + H2O + ferricytochrome c552
nitrite + ferrocytochrome c552 + 2 H+
show the reaction diagram
Marinobacter nauticus
-
-
-
-
?
nitrite + electron donor
NO + oxidized electron donor
show the reaction diagram
-
-
-
-
?
nitrite + electron donor
NO + oxidized electron donor + H2O
show the reaction diagram
-
mitochondrial electron carrier cytochrome c can also effectively reduce nitrite to NO. This nitrite reductase activity is highly regulated as it is dependent on pentacoordination of the heme iron in the protein and occurs under anoxic and acidic conditions. In the presence of nitrite, pentacoordinate cytochrome c generates bioavailable NO that is able to inhibit mitochondrial respiration
-
-
?
nitrite + ferrocytochrome c
NO + H2O + ferricytochrome c
show the reaction diagram
nitrite + ferrocytochrome c + 2 H+
nitric oxide + H2O + ferricytochrome c
show the reaction diagram
nitrite + ferrocytochrome c2
NO + H2O + ferricytochrome c2
show the reaction diagram
-
there is likely an unidentified electron donor, in addition to c2 that transfers electrons to nitrite reductase
-
-
?
nitrite + ferrocytochrome c550
NO + ferricytochrome c550
show the reaction diagram
-
-
-
-
?
nitrite + reduced azurin I
NO + oxidized azurin I
show the reaction diagram
-
coordinate synthesis of azurin I and copper nitrite reductase in Alcaligenes xylosoxidans during denitrification
-
-
?
nitrite + reduced electron donor
NO + H2O + oxidized electron donor
show the reaction diagram
nitrite + reduced pseudoazurin
NO + H2O + oxidized pseudoazurin
show the reaction diagram
-
-
-
-
?
nitrite + reduced pseudoazurin
NO + oxidized pseudoazurin
show the reaction diagram
NO2- + ferrocytochrome c
NO + ferricytochrome c
show the reaction diagram
NO2- + reduced cytochrome c550
NO + oxidized cytochrome c550
show the reaction diagram
-
unambiguously identified as physiological electron donor
-
?
NO2- + reduced pseudoazurin
NO + oxidized pseudoazurin
show the reaction diagram
-
unambiguously identified as physiological electron donor
-
?
reduced azurin + O2
oxidized azurin + H2O
show the reaction diagram
additional information
?
-