1.7.1.B3: aromatic nitroreductase [NADPH]

This is an abbreviated version, for detailed information about aromatic nitroreductase [NADPH], go to the full flat file.

Reaction

an aromatic amine
+ 3 NADP+ + 2 H2O =
an aromatic nitrate
+ 3 NADPH + 3 H+

Synonyms

ipa-43d, More, NADPH-FMN reductase, NADPH-nitrofurazone reductase, NfrA1, NfsA, nitro/flavin reductase, nitrofurazone reductase, nitroreductase A, non-luminescent-bacterial NfsA/Frp-type enzyme, oxygen-insensitive nitroreductase (NADPH)

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.B3 aromatic nitroreductase [NADPH]

Reference

Reference on EC 1.7.1.B3 - aromatic nitroreductase [NADPH]

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Valiauga, B.; Williams, E.M.; Ackerley, D.F.; Cenas, N.
Reduction of quinones and nitroaromatic compounds by Escherichia coli nitroreductase A (NfsA) Characterization of kinetics and substrate specificity
Arch. Biochem. Biophys.
614
14-22
2017
Escherichia coli
Manually annotated by BRENDA team
Zenno, S.; Kobori, T.; Tanokura, M.; Saigo, K.
Purification and characetrizatio of NfrA1, a Bacillus subtilis nitro/flavin reductase capable of interacting with the bacterial luciferase
Biosci. Biotechnol. Biochem.
62
1978-1987
1998
Bacillus subtilis, Bacillus subtilis ISW 1214
Manually annotated by BRENDA team
Yang, J.; Zhan, J.; Bai, J.; Liu, P.; Xue, Y.; Yang, Q.
Residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA
Biotechnol. Lett.
35
1693-1700
2013
Escherichia coli (P17117)
Manually annotated by BRENDA team
Green, L.K.; Syddall, S.P.; Carlin, K.M.; Bell, G.D.; Guise, C.P.; Mowday, A.M.; Hay, M.P.; Smaill, J.B.; Patterson, A.V.; Ackerley, D.F.
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI - a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy
Mol. Cancer
12
58
2013
Escherichia coli (P17117)
Manually annotated by BRENDA team
Bai, J.; Yang, J.; Liu, P.; Yang, Q.
Transformation pathway of 2,4,6-trinitrotoluene by Escherichia coli nitroreductases and improvement of activity using structure-based mutagenesis
Process Biochem.
50
705-711
2015
Escherichia coli (P17117)
Manually annotated by BRENDA team