1.7.1.B3: aromatic nitroreductase [NADPH]
This is an abbreviated version!
For detailed information about aromatic nitroreductase [NADPH], go to the full flat file.
Word Map on EC 1.7.1.B3
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1.7.1.B3
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hypoplasia
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dermal
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x-linked
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goltz
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ectodermal
-
malformation
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ocular
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porcupine
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mesoderm
-
blaschko
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skew
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x-chromosome
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postzygotic
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teeth
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goltz-gorlin
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multisystemic
-
herniation
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diaphragmatic
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x-inactivation
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angioma
-
papillomas
-
hernia
-
wingless
-
cutis
-
nail
-
o-acyltransferase
-
aplasia
-
patchy
-
environmental protection
-
medicine
- 1.7.1.B3
-
hypoplasia
-
dermal
-
x-linked
-
goltz
-
ectodermal
-
malformation
-
ocular
-
porcupine
-
mesoderm
-
blaschko
-
skew
-
x-chromosome
-
postzygotic
-
teeth
-
goltz-gorlin
-
multisystemic
-
herniation
-
diaphragmatic
-
x-inactivation
-
angioma
-
papillomas
-
hernia
-
wingless
-
cutis
-
nail
-
o-acyltransferase
-
aplasia
-
patchy
- environmental protection
- medicine
Reaction
+ 3 NADP+ + 2 H2O = + 3 NADPH + 3 H+
Synonyms
ipa-43d, More, NADPH-FMN reductase, NADPH-nitrofurazone reductase, NfrA1, NfsA, nitro/flavin reductase, nitrofurazone reductase, nitroreductase A, non-luminescent-bacterial NfsA/Frp-type enzyme, NR-A, ORF 17150, oxygen-insensitive NAD(P)H:nitroreductases, oxygen-insensitive nitroreductase (NADPH)
ECTree
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General Information
General Information on EC 1.7.1.B3 - aromatic nitroreductase [NADPH]
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evolution
physiological function
additional information
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analysis of evolutionary or molecular mechanism of divergence of the nitroreductase/flavin reductase family, overview. The enzyme is similar to NfsA from Escherichia coli, overview
evolution
nitroreductases are a family of flavoproteins that catalyze the NAD(P)H-dependent reduction of nitro groups to hydroxylamino and/or amino groups on various nitro-substituted compounds
evolution
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analysis of evolutionary or molecular mechanism of divergence of the nitroreductase/flavin reductase family, overview. The enzyme is similar to NfsA from Escherichia coli, overview
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NfsA has potential applications in the biodegradation of nitroaromatic environment pollutants, e.g. explosives, and is also of interest for the anticancer strategy gene-directed enzyme prodrug therapy
physiological function
residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA, Phe42 is important for maintaining NfsA activity and structure
physiological function
enzyme is a flavoprotein with NADPH-dependent quinone reductase and nitroreductase activities
physiological function
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enzyme is a flavoprotein with NADPH-dependent quinone reductase and nitroreductase activities
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comparisons of the quantitative structure-activity relationships of single-electron reduction of quinones and nitroaromatic compounds by dehydrogenase (electron transferase) flavoenzymes, overview
additional information
the enzyme crystal structure of NfsA, PDB ID 1F5V, is used for molecular ligand docking studies