1.7.1.B2: aromatic nitroreductase [NAD(P)H]
This is an abbreviated version!
For detailed information about aromatic nitroreductase [NAD(P)H], go to the full flat file.
Reaction
+ 3 NAD(P)+ + 2 H2O = + 3 NAD(P)H + 3 H+
Synonyms
NfnB, NfsB, NfsB_Ec, NfsB_Pa, NprA, oxygen-insensitive nitroreductase (NAD(P)H), YfkO
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Natural Substrates Products on EC 1.7.1.B2 - aromatic nitroreductase [NAD(P)H]
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REACTION DIAGRAM
2,4,6-trinitrotoluene + NADH + H+
4-hydroxyamino-2,6-dinitrotoluene + NAD+ + H2O
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4-hydroxyamino-2,6-dinitrotoluene + NADP+ + H2O
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2,4,6-trinitrotoluene + NADPH + H+
4-hydroxyamino-2,6-dinitrotoluene + NADP+ + H2O
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Escherichia coli nitroreductase NfsB can reduce nitrochloromethylbenzindolines, i.e. nitro-CBIs, in an oxygen-independent fashion, generating highly cytotoxic metabolites that alkylate the N3 of adenine in the minor groove of DNA
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additional information
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Pseudomonas aeruginosa nitroreductase NfsB can reduce nitrochloromethylbenzindolines, i.e. nitro-CBIs, in an oxygen-independent fashion, generating highly cytotoxic metabolites that alkylate the N3 of adenine in the minor groove of DNA
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