1.7.1.15: nitrite reductase (NADH)
This is an abbreviated version!
For detailed information about nitrite reductase (NADH), go to the full flat file.
Reaction
+ 3 NAD+ + 2 H2O = + 3 NADH + 5 H+
Synonyms
assimilatory NADH-nitrite reductase, assimilatory nitrite reductase, BMWSH_4089, EC 1.6.6.4, NADH-dependent nitrite oxidoreductase, NADH-dependent nitrite reductase, NADH-nitrite oxidoreductase, NADH-nitrite reductase, NADH:nitrite oxidoreductase, NasB, NasB protein, nasD, NasDE, nasE, NIA1, Nia2, NiR, nirB, NirBD, nirD, nitrite reductase (reduced nicotinamide adenine dinucleotide)
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General Information
General Information on EC 1.7.1.15 - nitrite reductase (NADH)
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metabolism
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the enzyme is necessary for nitrate/nitrite assimilation but also either detoxify nitrite or carries out fermentative ammonification in support of anaerobic catabolism. The enzyme confers a significant benefit during fermentative growth that reflects fermentative ammonification rather than detoxification. Fermentative ammonification by the enzyme allows for the energetically favorable fermentation of glucose to formate and acetate
physiological function
isoform NIA1 is the more efficient nitrite reductase while isoform NIA2 exhibits higher nitrate reductase activity
physiological function
isoform NIA1 is the more efficient nitrite reductase while isoform NIA2 exhibits higher nitrate reductase activity, reaction of EC 1.7.1.1
physiological function
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the enzyme is a key contributor to regulation of the nitric oxide level during nitrate respiration