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1.6.99.1: NADPH dehydrogenase

This is an abbreviated version!
For detailed information about NADPH dehydrogenase, go to the full flat file.

Word Map on EC 1.6.99.1

Reaction

NADPH
+
H+
+
acceptor
=
NADP+
+
reduced acceptor

Synonyms

2-cyclohexen-1-one, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, EBP, Estrogen-binding protein, NADP-d, NADPH diaphorase, NADPH-d, NADPH-dehydrogenase, NADPH-dependent cyclohexenone reductase, NADPH-dependent diaphorase, NADPH-diaphorase, NADPH-methemoglobin reductase, NADPH2-dehydrogenase, NCR, nicotinamide adenine dinucleotide phosphate diaphorase, nitric oxide synthase, old yellow enzyme, Old yellow enzyme homolog, OYE, OYE1, OYE2, OYE3, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, SYE4, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, YqjM

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.99 With unknown physiological acceptors
                1.6.99.1 NADPH dehydrogenase

Reference

Reference on EC 1.6.99.1 - NADPH dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Saito, K.; Davio, M.; Lockridge, O.; Massey, V.
The cloning of old yellow enzyme
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
349-352
1990
Saccharomyces pastorianus
-
Manually annotated by BRENDA team
Fox, K.M.; Jacques, S.M.; Karplus, P.A.
Crystallization and characterization of old yellow enzyme
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
353-356
1990
Saccharomyces pastorianus
-
Manually annotated by BRENDA team
Miura, R.; Yamaichi, K.; Tagawa, K.; Miyake, Y.
On the structure of old yellow enzyme studied by specific limited proteolysis
J. Biochem.
102
1311-1320
1987
Saccharomyces pastorianus
Manually annotated by BRENDA team
Honma, T.; Ogura, Y.
Kinetic studies of the old yellow enzyme. I. The reaction mechanism of the enzyme with reduced nicotinamide adenine dinucleotide
Biochim. Biophys. Acta
484
9-23
1977
Saccharomyces pastorianus
Manually annotated by BRENDA team
Massey, V.; Schopfer, L.M.
Reactivity of old yellow enzyme with alpha-NADPH and other pyridine nucleotide derivatives
J. Biol. Chem.
261
1215-1222
1986
Saccharomyces pastorianus
Manually annotated by BRENDA team
Kemp, M.C.; Kuonene, D.R.; Roberts, P.J.
Kinetics of rat brain NADPH-diaphorase
Biochem. Soc. Trans.
15
501
1987
Rattus norvegicus
-
Manually annotated by BRENDA team
De-Faria, M.H.; do-Nascimento, J.L.M.; Paes-de-Carvalho, R.
Biochemical characterization of NADPH-diaphorase in the chick embryo retina: Stimulation by calcium ions and inhibition by arginine analogs
Braz. J. Med. Biol. Res.
28
252-255
1995
Gallus gallus
Manually annotated by BRENDA team
Kerschbaum, H.H.; Huang, S.; Xie, M.; Hermann, A.
NADPH-diaphorase activity and nitric oxide synthase activity in the kidney of the clawed frog, Xenopus laevis
Cell Tissue Res.
301
405-411
2000
Xenopus laevis
Manually annotated by BRENDA team
Spessert, R.; Layes, E.
Fixation conditions affect the intensity but not the pattern of NADPH-diaphorase staining as a marker for neuronal nitric oxide synthase in rat olfactory bulb
J. Histochem. Cytochem.
42
1309-1315
1994
Rattus norvegicus
Manually annotated by BRENDA team
Nakamura, H.
NADPH-diaphorase and cytosolic urea cycle enzymes in the rat spinal cord
J. Comp. Neurol.
385
616-626
1997
Rattus norvegicus
Manually annotated by BRENDA team
Schmidt, R.E.; Dorsey, D.A.; McDaniel, M.L.; Corbett, J.A.
Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia--effect of diabetes and aging
Brain Res.
617
343-348
1993
Rattus norvegicus
Manually annotated by BRENDA team
Stengl, M.; Zintl, R.
NADPH diaphorase activity in the antennae of the hawk moth Manduca sexta
J. Exp. Biol.
199
1063-1072
1996
Manduca sexta
Manually annotated by BRENDA team
Peng, Z.C.; Li, X.Q.; Liang, Q.H.; Zhu, C.X.; Luo, T.L.; Yan, X.X.; Hu, S.Y.
Induction of NADPH-diaphorase activity in the forebrain in a model of intracerebral hemorrhage and its inhibition by the traditional Chinese medicine complex Nao Yi An
Brain Res. Bull.
42
119-128
1997
Rattus norvegicus
Manually annotated by BRENDA team
Rabinowitz, S.S.; Lucas, J.J.; Gootman, P.M.
NADPH-diaphorase activity in piglet intestinal mucosa
Cell. Mol. Biol. Res.
41
73-80
1995
Sus scrofa
Manually annotated by BRENDA team
Fox, K.M.; Karplus, P.A.
The flavin environment in old yellow enzyme. An evaluation of insights from spectroscopic and artificial flavin studies
J. Biol. Chem.
274
9357-9362
1999
Saccharomyces pastorianus
Manually annotated by BRENDA team
Kohli, R.M.; Massey, V.
The oxidative half-reaction of old yellow enzyme. The role of tyrosine 196
J. Biol. Chem.
273
32763-32770
1998
Saccharomyces pastorianus
Manually annotated by BRENDA team
Poinas, A.; Gaillard, J.; Vignais, P.; Doussiere, J.
Exploration of the diaphorase activity of neutrophil NADPH oxidase. Critical assessment of the interaction of iodonitrotetrazolium with the oxidase redox components
Eur. J. Biochem.
269
1243-1252
2002
Bos taurus
Manually annotated by BRENDA team
Fox, K.M.; Karplus, P.A.
Old yellow enzyme at 2 ANG resolution: Overall structure, ligand binding, and comparison with related flavoproteins
Structure
2
1089-1105
1994
Saccharomyces pastorianus
Manually annotated by BRENDA team
Baum, O.; Miethke, A.; Wockel, A.; Willerding, G.; Planitzer, G.
The specificity of the histochemical NADPH diaphorase reaction for nitric oxide synthase-1 in skeletal muscles is increased in the presence of urea
Acta Histochem.
104
3-14
2002
Mus musculus
Manually annotated by BRENDA team
Kataoka, M.; Kotaka, A.; Hasegawa, A.; Wada, M.; Yoshizumi, A.; Nakamori, S.; Shimizu, S.
Old Yellow Enzyme from Candida macedoniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone
Biosci. Biotechnol. Biochem.
66
2651-2657
2002
Candida macedoniensis
Manually annotated by BRENDA team
Roda, E.; Municchi, E.; Conforti, E.; Pisu, M.B.; Gomulski, L.M.; Malacrida, A.R.; Bernocchi, G.
Nitric oxide synthase-dependent NADPH-diaphorase activity in the optic lobes of male and female Ceratitis capitata mutants
Eur. J. Histochem.
48
141-150
2004
Ceratitis capitata
Manually annotated by BRENDA team
Fitzpatrick, T.B.; Amrhein, N.; Macheroux, P.
Characterization of YqjM, an Old Yellow Enzyme homolog from Bacillus subtilis involved in the oxidative stress response
J. Biol. Chem.
278
19891-19897
2003
Bacillus subtilis
Manually annotated by BRENDA team
Haarer, B.K.; Amberg, D.C.
Old yellow enzyme protects the actin cytoskeleton from oxidative stress
Mol. Biol. Cell
15
4522-4531
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Fitzpatrick, T.B.; Auweter, S.; Kitzing, K.; Clausen, T.; Amrhein, N.; Macheroux, P.
Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation
Protein Expr. Purif.
36
280-291
2004
Bacillus subtilis
Manually annotated by BRENDA team
Trotter, E.W.; Collinson, E.J.; Dawes, I.W.; Grant, C.M.
Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae
Appl. Environ. Microbiol.
72
4885-4892
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nakagawa, M.; Yamano, T.; Kuroda, K.; Nonaka, Y.; Tojo, H.; Fujii, S.
A cytosolic cytochrome b5-like protein in yeast cell accelerating the electron transfer from NADPH to cytochrome c catalyzed by Old Yellow Enzyme
Biochem. Biophys. Res. Commun.
338
605-609
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Brige, A.; Van den Hemel, D.; Carpentier, W.; De Smet, L.; Van Beeumen, J.J.
Comparative characterization and expression analysis of the four Old Yellow Enzyme homologues from Shewanella oneidensis indicate differences in physiological function
Biochem. J.
394
335-344
2006
Shewanella oneidensis
Manually annotated by BRENDA team
Kim, M.J.; Kim, H.K.; Chung, J.H.; Lim, B.O.; Yamada, K.; Lim, Y.; Kang, S.A.
Increased expression of hypothalamic NADPH-diaphorase neurons in mice with iron supplement
Biosci. Biotechnol. Biochem.
69
1978-1981
2005
Mus musculus
Manually annotated by BRENDA team
Garbossa, D.; Fontanella, M.; Tomasi, S.; Ducati, A.; Vercelli, A.
Differential distribution of NADPH-diaphorase histochemistry in human cerebral cortex
Brain Res.
1034
1-10
2005
Homo sapiens
Manually annotated by BRENDA team
Dudina, Y.V.
Effect of kainate-induced experimental epilepsy on NADPH-diaphorase and calcium-binding proteins in rat hippocampal neurons
Bull. Exp. Biol. Med.
139
309-312
2005
Rattus norvegicus
Manually annotated by BRENDA team
Andronowska, A.; Wasowska, B.; Calka, J.; Doboszynska, T.
Localization and correlation between NADPH-diaphorase and nitric oxide synthase isoforms in the porcine uterus during the estrous cycle
Cell Tissue Res.
321
243-250
2005
Sus scrofa
Manually annotated by BRENDA team
Racekova, E.; Martoncikova, M.; Mitruskova, B.; Cizkova, D.; Orendacova, J.
Age-related changes of NADPH-diaphorase positivity in the rat rostral migratory stream
Cell. Mol. Neurobiol.
25
1093-1105
2005
Rattus norvegicus
Manually annotated by BRENDA team
Torres, J.B.; Assuncao, J.; Farias, J.A.; Kahwage, R.; Lins, N.; Passos, A.; Quintairos, A.; Trevia, N.; Diniz, C.W.
NADPH-diaphorase histochemical changes in the hippocampus, cerebellum and striatum are correlated with different modalities of exercise and watermaze performances
Exp. Brain Res.
175
292-304
2006
Mus musculus
Manually annotated by BRENDA team
Reekmans, R.; De Smet, K.; Chen, C.; Van Hummelen, P.; Contreras, R.
Old yellow enzyme interferes with Bax-induced NADPH loss and lipid peroxidation in yeast
FEMS Yeast Res.
5
711-725
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Pragasam, V.; Sakthivel, R.; Kalaiselvi, P.; Rajesh, N.G.; Varalakshmi, P.
Detection of endothelial nitric oxide synthase and NADPH-diaphorase in experimentally induced hyperoxaluric animals
Urol. Res.
33
301-308
2005
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Coyle, C.M.; Cheng, J.Z.; OConnor, S.E.; Panaccione, D.G.
An old yellow enzyme gene controls the branch point between Aspergillus fumigatus and Claviceps purpurea ergot alkaloid pathways
Appl. Environ. Microbiol.
76
3898-3903
2010
Trypanosoma cruzi (Q2TJB8)
Manually annotated by BRENDA team
Rigon, F.; Rossato, D.; Auler, V.B.; Dal Bosco, L.; Faccioni-Heuser, M.C.; Partata, W.A.
Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion
Braz. J. Med. Biol. Res.
46
513-520
2013
Lithobates catesbeianus
Manually annotated by BRENDA team
Okamoto, N.; Yamaguchi, K.; Mizohata, E.; Tokuoka, K.; Uchiyama, N.; Sugiyama, S.; Matsumura, H.; Inaka, K.; Urade, Y.; Inoue, T.
Structural insight into the stereoselective production of PGF2alpha by old yellow enzyme from Trypanosoma cruzi
J. Biochem.
150
563-568
2011
Trypanosoma cruzi
Manually annotated by BRENDA team
Zou, T.; Zheng, L.; Yuan, H.; Yuan, Y.; Wang, J.
The nitric oxide production and NADPH-diaphorase activity in root tips of Vicia faba L. under copper toxicity
Plant OMICS
5
115-121
2012
Vicia faba
-
Manually annotated by BRENDA team
Classen, T.; Pietruszka, J.; Schuback, S.
Revisiting the enantioselective sequence patterns in enoate reductases
ChemCatChem
5
711-713
2013
Zymomonas mobilis, Zymomonas mobilis ATCC 29191
-
Manually annotated by BRENDA team
Lonsdale, R.; Reetz, M.T.
Reduction of alpha,beta-unsaturated ketones by old yellow enzymes: mechanistic insights from quantum mechanics/molecular mechanics calculations
J. Am. Chem. Soc.
137
14733-14742
2015
Bacillus subtilis, Bacillus subtilis 168
Manually annotated by BRENDA team
Kudisch, B.; Oblinsky, D.G.; Black, M.J.; Zieleniewska, A.; Emmanuel, M.A.; Rumbles, G.; Hyster, T.K.; Scholes, G.D.
Active-site environmental factors customize the photophysics of photoenzymatic old yellow enzymes
J. Phys. Chem. B
124
11236-11249
2020
Saccharomyces pastorianus (Q02899)
Manually annotated by BRENDA team