Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.6.5.2: NAD(P)H dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about NAD(P)H dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.2

Reaction

NAD(P)H
+
H+
+
a quinone
=
NAD(P)+
+
a hydroquinone

Synonyms

1,4-benzoquinone reductase, azoreductase, chromate reductase, ChrR, dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone), diaphorase, DPND, DPNH-diaphorase, DT-diaphorase, DTD, DVU_2399, DVU_2400, DVU_2401, EC 1.6.99.2, FerB, ferric reductase B, flavoprotein NAD(P)H-quinone reductase, FlxABCD, FMN-dependent NAD(P)H:quinone oxidoreductase, Internal NADH dehydrogenase, MdaB, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase complex, NAD(P)H menadione reductase, NAD(P)H quinone oxidoreductase, NAD(P)H quinone oxidoreductase-1, NAD(P)H quinone oxidoreductase1, NAD(P)H quinone reductase, NAD(P)H quinone-oxidoreductase 1, NAD(P)H-QR, NAD(P)H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H: (quinone acceptor) oxidoreductase, NAD(P)H: (quinone-acceptor)oxidoreductase, NAD(P)H: menadione oxidoreductase, NAD(P)H: Quinone oxidoreductase, NAD(P)H: quinone oxidoreductase 1, NAD(P)H: quinone oxidoreductase-1, NAD(P)H: quinone reductase, NAD(P)H:acceptor oxidoreductase, NAD(P)H:quinone acceptor oxidoreductase, NAD(P)H:quinone oxidoreducatase 1, NAD(P)H:quinone oxidoreductase, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxidoreductase I, NAD(P)H:quinone oxidoreductase-1, NAD(P)H:quinone reductase, NAD(P)H:quinoneoxidoreductase 1, NADH-menadione reductase, NADH:quinone oxidoreductase 1, NADPH quinone reductase, NADPH: quinone oxidoreductase-1, NADPH:quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NAD[P]H:quinone acceptor oxidoreductase 1, Naphthoquinone reductase, Ndh complex, NDH2, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, NQO1, NQR, NRH:quinone reductase 1, p-Benzoquinone reductase, Pden_4071, PfNdh2, Phylloquinone reductase, QOR2, QR1, QR2, Quinone reductase, quinone reductase 1, quinone reductase type 1, Reduced NAD(P)H dehydrogenase, reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase, TcpB, TmQR2, type II NADH: quinone oxidoreductase, Viologen accepting pyridine nucleotide oxidoreductase, Vitamin K reductase, vitamin-K reductase, WrbA

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.2 NAD(P)H dehydrogenase (quinone)

Source Tissue

Source Tissue on EC 1.6.5.2 - NAD(P)H dehydrogenase (quinone)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low NQO1 activity. The redox dye 2,6-dichlorophenolindophenol may serve as a prooxidant chemotherapeutic targeting human melanoma cells in vitro and in vivo. DCPIP-apoptogenicity observed in the human melanoma cell lines A375 and G361 is inversely correlated with NAD(P)H:quinone oxidoreductase (NQO1) expression levels. 2,6-Dichlorophenolindophenol apoptogenic potency observed in human A375 and G361 melanoma cells is a function of cellular NQO1 expression levels
Manually annotated by BRENDA team
-
pulmonary arterial endothelial cell. Increase in enzyme protein and activity upon hyperoxia, i.e. exposure to 95% O2 for 48 h
Manually annotated by BRENDA team
-
enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages
Manually annotated by BRENDA team
-
wild-type p53immortalized B-cell lymphoblasts from individuals with heterozygous NQO1; homozygous NQO1+/- and missing NQO1, LBL51
Manually annotated by BRENDA team
-
the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimer‘s disease versus controls
Manually annotated by BRENDA team
-
the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimer‘s disease versus controls
Manually annotated by BRENDA team
NQO1-deficient BE and NQO1-rich BE-NQ
Manually annotated by BRENDA team
-
recombinant human NQO1
Manually annotated by BRENDA team
-
pulmonary arterial, sulforaphane-treated
Manually annotated by BRENDA team
the gene for QR2 is isolated from an expressed sequence tag collection derived from the epidermis of a diploid Triticum monococcum L. 24 h after inoculation with the powdery mildew fungus Blumeria graminis EO Speer f. sp. tritici Em. Marchal. TmQR1 is repressed while TmQR2 is induced in the epidermis during powdery mildew infection. TmQR2 can play a role in protecting the infected epidermis
Manually annotated by BRENDA team
-
the redox dye 2,6-dichlorophenolindophenol may serve as a prooxidant chemotherapeutic targeting human melanoma cells in vitro and in vivo. DCPIP-apoptogenicity observed in the human melanoma cell lines A375 and G361 is inversely correlated with NAD(P)H:quinone oxidoreductase (NQO1) expression levels. 2,6-Dichlorophenolindophenol apoptogenic potency observed in human A375 and G361 melanoma cells is a function of cellular NQO1 expression levels
Manually annotated by BRENDA team
up-regulation of enzyme upon exposure to L-dopa and tetrahydropapaveroline
Manually annotated by BRENDA team
no correlation between NQO1 activity in rectal biopsies and NQO1 activity in total lymphocytes. No correlation between total leukocyte and lymphocyte NQO1 activity
Manually annotated by BRENDA team
-
enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages
Manually annotated by BRENDA team
-
human breast cancer cell line lacking enzyme due to genetic polymorphism
Manually annotated by BRENDA team
-
p53 mutant MDA-MB-157 and MDAMB-231, dominant negative p53
Manually annotated by BRENDA team
additional information