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1.6.3.2: NAD(P)H oxidase (H2O-forming)

This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O-forming), go to the full flat file.

Reaction

2 NADPH +

H+
+
O2
= 2 NADP+ + 2 H2O

Synonyms

KOD1, NAD(P)H oxidase, NOX, NOXtp, TK1299

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.2 NAD(P)H oxidase (H2O-forming)

Natural Substrates Products

Natural Substrates Products on EC 1.6.3.2 - NAD(P)H oxidase (H2O-forming)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 NAD(P)H + H+ + O2
NAD(P)+ + 2 H2O
show the reaction diagram
in anaerobes, flavin-dependent NAD(P)H oxidases play an important role protecting organisms from oxidative stress
-
-
?
2 NADH + H+ + O2
NAD+ + 2 H2O
show the reaction diagram
reaction is catalyzed by the native dimeric protein under physiological conditions (low amounts of O2) to detoxify O2. Oxidative stress induced conformational change implicates a functional switch of the enzyme. The oxidized enzyme protein can accelerate the aggregation of partially unfolded proteins. It can also bind nucleic acids and produce H2O2 to destroy DNA and RNA with the ultimate function of decreasing cell viability
-
-
?
2 NADPH + 2 H+ + O2
2 NADP+ + 2 H2O
show the reaction diagram
NADH + H+ + O2
NAD+ + H2O
show the reaction diagram
NADPH + H+ + O2
NADP+ + H2O
show the reaction diagram