1.6.3.2: NAD(P)H oxidase (H2O-forming)
This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O-forming), go to the full flat file.
Reaction
Synonyms
KOD1, NAD(P)H oxidase, NOX, NOXtp, TK1299
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 1.6.3.2 - NAD(P)H oxidase (H2O-forming)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
2 NAD(P)H + H+ + O2
NAD(P)+ + 2 H2O
in anaerobes, flavin-dependent NAD(P)H oxidases play an important role protecting organisms from oxidative stress
-
-
?
2 NADH + H+ + O2
NAD+ + 2 H2O
reaction is catalyzed by the native dimeric protein under physiological conditions (low amounts of O2) to detoxify O2. Oxidative stress induced conformational change implicates a functional switch of the enzyme. The oxidized enzyme protein can accelerate the aggregation of partially unfolded proteins. It can also bind nucleic acids and produce H2O2 to destroy DNA and RNA with the ultimate function of decreasing cell viability
-
-
?
2 NADPH + 2 H+ + O2
2 NADP+ + 2 H2O
the enzyme may be involved in maintenance of an optimum intracellular redox ratio
-
-
?
2 NADPH + 2 H+ + O2
2 NADP+ + 2 H2O
the enzyme may be involved in maintenance of an optimum intracellular redox ratio
-
-
?
2 NADPH + 2 H+ + O2
2 NADP+ + 2 H2O
reaction is catalyzed by the native dimeric protein under physiological conditions (low amounts of O2) to detoxify O2. Oxidative stress induced conformational change implicates a functional switch of the enzyme. The oxidized enzyme protein can accelerate the aggregation of partially unfolded proteins. It can also bind nucleic acids and produce H2O2 to destroy DNA and RNA with the ultimate function of decreasing cell viability
-
-
?
NADPH + H+ + O2
NADP+ + H2O
the enzyme prefers NADPH over NADH
-
-
?