1.6.3.2: NAD(P)H oxidase (H2O-forming)
This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O-forming), go to the full flat file.
Reaction
Synonyms
KOD1, NAD(P)H oxidase, NOX, NOXtp, TK1299
ECTree
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General Information
General Information on EC 1.6.3.2 - NAD(P)H oxidase (H2O-forming)
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physiological function
in anaerobes, flavin-dependent NAD(P)H oxidases play an important role protecting organisms from oxidative stress
physiological function
NAD(P)H oxidase reaction is catalyzed by the native dimeric protein under physiological conditions (low amounts of O2) to detoxify O2. Oxidative stress induced conformational change implicates a functional switch of the enzyme. The oxidized enzyme protein can accelerate the aggregation of partially unfolded proteins. It can also bind nucleic acids and produce H2O2 to destroy DNA and RNA with the ultimate function of decreasing cell viability
physiological function
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overexpression of this enzyme in Giardia results in significantly enhanced growth under aerobic conditions. NADH oxidase could be thus an instrumental enzyme for the organism to adapt to and to tolerate an aerobic living environment
physiological function
the enzyme may be involved in maintenance of an optimum intracellular redox ratio
physiological function
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the enzyme may be involved in maintenance of an optimum intracellular redox ratio
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