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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone + NADPH
NADP+ + ?
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i.e. RH1, the enzyme reduces the antitumor drug RH1 to a semiquinone free radical. Following this reduction RH1 undergoes redox cycling under oxic conditions to produce potentially damaging hydroxyl radicals
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
paraquat + NADPH
?
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paraquat is a toxic herbicide
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additional information
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
Coleus scutellarioides
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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NADPH-cytochrome P450 reductase is a unique universal donor of electrons to practically all known microsomal cytochrome P450s and one of the most important components of the monooxygenase system
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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involved in drug metabolism
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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component of the cytochrome P450 dependent monooxygenase system
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
Coleus scutellarioides
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
Corbula caribea
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component of the mixed function oxygenase system
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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involved in drug metabolism
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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involved in drug metabolism, reduced cytochrome P450 is essential for drug metabolism
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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involved in drug metabolism, NADPH-cytochrome P450 deletion mouse is resistant to acetaminophen concentrations at doses toxic for normal mice
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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component of the cytochrome P450 dependent monooxygenase system
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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transfer of electrons during the CYP catalytic cycle
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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involved in the hydroxylation of progesterone at the 11alpha position
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
involved in activation of cytochrome P450 monooxygenase systems
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
involved in activation of cytochrome P450 monooxygenase systems
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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part of the microsomal electron-transport chains and responsible for the transfer of reducing equivalents between NADPH or NADH and cytochrome P-450
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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component of the hydroxylation of lauric acid
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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during hydroxylation of alkanes
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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part of the microsomal electron-transport chains and responsible for the transfer of reducing equivalents between NADPH or NADH and cytochrome P-450
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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during ecdysone hydroxylation
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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during hydroxylation of fatty acids through the bacterial fusion protein P450BM3
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NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
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NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
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NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
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additional information
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monooxygenase system only present in cells grown on alkanes
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additional information
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monooxygenase system composed of cytochrome P-450, NADPH-cytochrome c reductase, phospholipids
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additional information
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monooxygenase system composed of cytochrome P450, cytochrome b5 and NADPH cytochrome c P450 reductase
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additional information
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disruption of redA leads to mutant cells that form yellow mounds that fail to make proper fruiting bodies. The developmental arrest shown by this mutant implicates redA-encoded P450 oxidoreductase in the metabolism of compounds that control cell differentiation
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additional information
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CYP3A related metabolism in horse is dependent on the expression of the enzyme and also on adequate levels of NADPH P450 reductase and cytochrome b5
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additional information
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electron transport system composed of cytochrome P-450, cytochrome b5-like hemeproteins, NADPH cytochrome c reductase, and NADH-ferricyanide reductase
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additional information
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P450 Red does not contribute to the activation of RH1 (i.e. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone) in cells with normal P450 Red activity and plays only a minor role in activating this agent in cells with high levels of this enzyme
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additional information
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CYPOR is involved in reduction of the prodrug PR-104A
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additional information
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functional assays studying the effects of specific POR mutations on steroidogenesis shows that several POR variants impair CYP17A1, CYP21A2 and CYP19A1 activities to different degrees
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additional information
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P450R function is essential for cytochrome P450 activity. The enzyme provides the electrons used in P450-mediated reactions using NADPH as a cofactor. P450R-transfected MDA 231 breast cells display increased sensitivity to mitomycin C and 5-fluorouracil as compared to their empty-vector transfected counterparts. NADPH levels are decreased in P450R-overexpressing cells
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additional information
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the bioreductive agent RH1 can be reduced by the enzyme. RH1 produces DNA strand breaks and crosslinks in isolated DNA after reduction by P450 Red. P450 Red does not play a significant role in activating RH1 in cells with normal P450 Red activity
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additional information
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the enzyme donates electrons derived from NADPH to a variety of acceptor proteins, including squalene monooxygenase, 7-dehydro-cholesterol reductase, heme oxygenase, cytochrome b5 , and many microsomal cytochromes P450
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additional information
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binding of cytochrome P450 2B4 to cytochrome b5 and cytochrome P450 reductase, binding site on cytochrome P450 2B4 for its redox partners, complex formation modelling, overview
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additional information
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monooxygenase system composed of ecdysone 20-monooxygenase, cytochrome P-450 and NADPH-cytochrome c reductase
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additional information
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acts as an electron transfer component of the alkane monoxygenase system
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additional information
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acts as an electron transfer component of the alkane monoxygenase system
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additional information
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component of the microsomal electron transport system
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additional information
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CPR, the obligate electron donor for microsomal P450 enzymes, is essential for the bioactivation of many procarcinogens
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additional information
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deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity
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additional information
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major effect of POR is on ellipticine detoxication (formation of 9-hydroxyellipticine by microsomal CYPs), and less on its oxidative activation to 12-hydroxy and 13-hydroxyellipticine
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additional information
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component of the microsomal electron transport system
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additional information
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mixed function oxidase system composed of cytochrome P-450, NADPH-cytochrome c reductase and phospholipids, biotransformation of airborne compounds
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additional information
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part of the bacterial fusion protein P450BM3 composed of cytochrome P450 fatty acid hydroxylase and NADPH cytochrome P450 reductase
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additional information
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detoxification of drugs, inactivation of procarcinogens
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additional information
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monooxygenase system composed of cytochrome P-450, NADPH-cytochrome c reductase, phospholipids
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additional information
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microsomal heme oxygenase system composed of heme oxygenase and NADPH-cytochrome c reductase catalyzes the oxidative degradation of heme to biliverdin, essential role in the physiological heme catabolism
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additional information
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the C-terminal 23 amino acids of heme oxygenase-1 play an important role in the interaction between heme oxygenase-1 and NADPH cytochrome P450 reductase, enhancing the conversion of hemin to biliverdin
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additional information
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the presence of NADPH-cytochrome P450 reductase prevents heme oxygenase-1 from acetylation of lysine residues, Lys149 and Lys153, located in the F-helix. The heme degradation activity of the fully acetylated heme oxygenase-1 in the NADPH/NADPH-cytochrome P450 reductase-supported system is significantly reduced, whereas almost no inactivation is detected in heme oxygenase-1 in the presence of NADPH-cytochrome P450 reductase, which prevents acetylation of Lys149 and Lys153
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additional information
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detoxification of drugs, inactivation of procarcinogens
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additional information
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monooxygenase system composed of cytochrome P-450, NADPH-cytochrome c reductase, phospholipids
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additional information
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microsomal electron transport system composed of cytochrome b5, cytochrome P450, NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase
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additional information
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microsomal electron transport system composed of cytochrome b5, cytochrome P450, NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase
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additional information
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microsomal electron transport system composed of cytochrome b5, cytochrome P450, NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase
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additional information
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involved in the sterol biosynthesis pathways
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additional information
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involved in the sterol biosynthesis pathways
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additional information
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mixed-function oxidase system composed of cytochrome P450, NADPH cytochrome P450 reductase and lipid
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additional information
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cytochrome P450 monooxygenase gets reducing equivalents from NADPH cytochrome P450 reductase
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additional information
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cytochrome P450 monooxygenase gets reducing equivalents from NADPH cytochrome P450 reductase
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additional information
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microsomal heme oxygenase system composed of heme oxygenase and NADPH-cytochrome c reductase catalyzes the oxidative degradation of heme to biliverdin, essential role in the physiological heme catabolism
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