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1.6.1.1: NAD(P)+ transhydrogenase (Si-specific)

This is an abbreviated version!
For detailed information about NAD(P)+ transhydrogenase (Si-specific), go to the full flat file.

Word Map on EC 1.6.1.1

Reaction

NADPH
+
NAD+
=
NADP+
 +
NADH

Synonyms

energy-independent soluble pyridine nucleotide transhydrogenase, H+-thase, NAD transhydrogenase, NAD(P) transhydrogenase, NAD(P)(+) transhydrogenase [B-specific], NADH transhydrogenase, NADH-NADP-transhydrogenase, NADPH-NAD oxidoreductase, NADPH-NAD transhydrogenase, NADPH:NAD+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, nicotinamide nucleotide transhydrogenase, NNT, non-energy-linked transhydrogenase, pyridine nucleotide transferase, pyridine nucleotide transhydrogenase, soluble pyridine nucleotide transhydrogenase, soluble transhydrogenase, STH, SthA, transhydrogenase, transhydrogenase, nicotinamide adenine dinucleotide (phosphate), UdhA

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.1 With NAD+ or NADP+ as acceptor
                1.6.1.1 NAD(P)+ transhydrogenase (Si-specific)

Inhibitors

Inhibitors on EC 1.6.1.1 - NAD(P)+ transhydrogenase (Si-specific)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-AMP
2-mercaptoethanol
-
5'-AMP
-
5 mM, 92% inhibition of NADP+ reduction, complete inhibition of NAD+ reduction
ADP
-
5 mM, 94% inhibition of NADP+ reduction, complete inhibition of NAD+ reduction
arsenate
-
complete inhibition of activity in either direction
ATP
-
5 mM, 81% inhibition of NADP+ reduction, complete inhibition of NAD+ reduction
beta-mercaptoethanol
72% residual activity at 0.2% (v/v)
Ca2+
91.2% residual activity at 2 mM; slightly inhibitory
CTP
-
5 mM, 86% inhibition of NADP+ reduction
Cu2+
complete inhibition at 2 mM
deoxycholate
-
-
diphosphate
-
5 mM, 91% inhibition of NADP+ reduction
dithiothreitol
75.3% residual activity at 2 mM
DMSO
slightly inhibitory
EDTA
72.6% residual activity at 2 mM
GTP
-
5 mM, 89% inhibition of NADP+ reduction
Mn2+
67% residual activity at 2 mM
NAD+
-
competitive to thio-NAD+, uncompetitive with respect to NADPH
NADP+
NADPH
EcSTH activity is strongly inhibited by excess NADPH, but not by thio-NAD+; the enzyme is strongly inhibited by excess NADPH
Ni2+
7.4% residual activity at 2 mM
p-Aminophenylarsenoxide
-
0.1 mM, 40-60% inhibition in the absence of either phosphate or magnesium ions, reduction of NAD+ by NADPH in cell-free extracts is rapidly and completely inhibited in the presence of 20 mM phosphate
p-chloromercuribenzoate
-
0.044 mM, 40-50% inhibition after 30 min, activity can be restored by adding 2-mercaptoethanol
p-hydroxymercuribenzoate
phosphate
phosphoenolpyruvate
-
87% inhibition of NADP+ reduction
pyridoxal 5'-phosphate
-
5 mM, 91% inhibition of NADP+ reduction
TTP
-
2 mM, 71% inhibition of NADP+ reduction
Zn2+
10.1% residual activity at 2 mM
additional information
-