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1.5.99.4: nicotine dehydrogenase

This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.4

Reaction

(S)-nicotine
+
acceptor
+
H2O
=
(S)-6-hydroxynicotine
+
reduced acceptor

Synonyms

6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.4 nicotine dehydrogenase

Reference

Reference on EC 1.5.99.4 - nicotine dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nagel, M.; Koenig, K.; Andreesen, J.R.
Bactopterin as component of eubacterial dehydrogenases involved in hydroxylation reactions initiating the degradation of nicotine, nicotinate, and 2-furancarboxylate
FEMS Microbiol. Lett.
60
323-326
1989
Pseudarthrobacter oxydans
-
Manually annotated by BRENDA team
Schenk, S.; Hoelz, A.; Krauss, B.; Decker, K.
Gene structures and properties of enzymes of the plasmid-encoded nicotine catabolism of Arthrobacter nicotinovorans
J. Mol. Biol.
284
1323-1339
1998
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Grether-Beck, S.; Igloi, G.L.; Pust, S.; Schilz, E.; Decker, K.; Brandsch, R.
Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans
Mol. Microbiol.
13
929-936
1994
Paenarthrobacter nicotinovorans (Q93NH4), Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Decker, K.; Bleeg, H.
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans
Biochim. Biophys. Acta
105
313-324
1965
Pseudarthrobacter oxydans
Manually annotated by BRENDA team
Freudenberg, W.; Koenig, K.; Andreesen, J.R.
Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase
FEMS Microbiol. Lett.
52
13-18
1988
Pseudarthrobacter oxydans
-
Manually annotated by BRENDA team
Hochstein, L.L.; Dalton, B.P.
The purification and properties of nicotine oxidase
Biochim. Biophys. Acta
139
56-68
1967
Pseudarthrobacter oxydans
Manually annotated by BRENDA team
Williams, D.E.; Ding, X.; Coon, M.J.
Rabbit nasal cytochrome P-450 NMa has high activity as a nicotine oxidase
Biochem. Biophys. Res. Commun.
166
945-952
1990
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nakayama, H.; Nakashima, T.; Kurogochi, Y.
Heterogeneity of hepatic nicotine oxidase
Biochim. Biophys. Acta
715
254-257
1982
Rattus norvegicus
Manually annotated by BRENDA team
Jones, M.V.
Cytochrome c linked nicotinic acid hydroxylase in Pseudomonas ovalis chester
FEBS Lett.
32
321-324
1973
Pseudomonas putida, Pseudomonas putida Chester
Manually annotated by BRENDA team
Behrman, E.J.; Stanier, R.Y.
The bacterial oxidation of nicotinic acid
J. Biol. Chem.
228
923-945
1957
Pseudomonas fluorescens, Pseudomonas fluorescens N-9
Manually annotated by BRENDA team
Igloi, G.L.; Brandsch, R.
Sequence of the 165-kilobase catabolic plasmid pAO1 from Arthrobacter nicotinovorans and identification of a pAO1-dependent nicotine uptake system
J. Bacteriol.
185
1976-1986
2003
Paenarthrobacter nicotinovorans (Q59127), Paenarthrobacter nicotinovorans (Q59128), Paenarthrobacter nicotinovorans (Q59129)
Manually annotated by BRENDA team
Sandu, C.; Chiribau, C.B.; Brandsch, R.
Characterization of HdnoR, the transcriptional repressor of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter nicotinovorans pAO1, and its DNA-binding activity in response to L- and D-nicotine Derivatives
J. Biol. Chem.
278
51307-51315
2003
Paenarthrobacter nicotinovorans (Q59127), Paenarthrobacter nicotinovorans (Q59128), Paenarthrobacter nicotinovorans (Q59129)
Manually annotated by BRENDA team
Sachelaru, P.; Schiltz, E.; Brandsch, R.
A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans
Appl. Environ. Microbiol.
72
5126-5131
2006
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Ganas, P.; Sachelaru, P.; Mihasan, M.; Igloi, G.L.; Brandsch, R.
Two closely related pathways of nicotine catabolism in Arthrobacter nicotinovorans and Nocardioides sp. strain JS614
Arch. Microbiol.
189
511-517
2008
Paenarthrobacter nicotinovorans, Nocardioides sp.
Manually annotated by BRENDA team
Qiu, J.; Ma, Y.; Zhang, J.; Wen, Y.; Liu, W.
Cloning of a novel nicotine oxidase gene from Pseudomonas sp. strain HZN6 whose product nonenantioselectively degrades nicotine to pseudooxynicotine
Appl. Environ. Microbiol.
79
2164-2171
2013
no activity in Pseudomonas putida strain KT2440, no activity in Escherichia coli strain DH5alpha, Pseudomonas sp. (M4T5L3), Pseudomonas sp. HZN6 (M4T5L3)
Manually annotated by BRENDA team
Li, H.; Xie, K.; Yu, W.; Hu, L.; Huang, H.; Xie, H.; Wang, S.
Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33
Appl. Environ. Microbiol.
82
1745-1755
2016
Agrobacterium tumefaciens, Agrobacterium tumefaciens S33
Manually annotated by BRENDA team
Qiu, J.; Li, N.; Lu, Z.; Yang, Y.; Ma, Y.; Niu, L.; He, J.; Liu, W.
Conversion of nornicotine to 6-hydroxy-nornicotine and 6-hydroxy-myosmine by Shinella sp. strain HZN7
Appl. Microbiol. Biotechnol.
100
10019-10029
2016
Shinella sp. HZN7 (A0A0Y0MN26)
Manually annotated by BRENDA team
Yu, W.; Wang, R.; Huang, H.; Xie, H.; Wang, S.
Periplasmic nicotine dehydrogenase NdhAB utilizes pseudoazurin as its physiological electron acceptor in Agrobacterium tumefaciens S33
Appl. Environ. Microbiol.
83
e01050
2017
Agrobacterium tumefaciens, Agrobacterium tumefaciens S33
Manually annotated by BRENDA team