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1.5.99.12: cytokinin dehydrogenase

This is an abbreviated version!
For detailed information about cytokinin dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.12

Reaction

N6-dimethylallyladenine
+
acceptor
+
H2O
=
adenine
+
3-methylbut-2-enal
+
reduced acceptor

Synonyms

AtCKX2, AtCKX3, AtCKX6, AtCKX7, CKO, CKO1, CKX, CKX1, CKX10, CKX12, CKX2, CKX2-2, CKX3, CKX4, CKX4a, CKX5, CKX6, CKX7, CKX8, CKX9, cytokinin dehydrogenase, cytokinin dehydrogenase 1, cytokinin dehydrogenase CKX1, cytokinin dehydrogenase CKX10, cytokinin oxidase, cytokinin oxidase/dehydrogenase, DhCKX, HvCKX1, isopentenyladenosine oxidase, More, N6-(D2-isopentenyl)adenosine oxidase, N6-dimethylallyladenine dehydrogenase, N6-isopentenylaldenine oxidase, OsCKX2, PsCKX1, PsCKX2, VIT_00s0252g00040, VIT_00s2520g00010, VIT_04s0008g01880, VIT_07s0005g05960, VIT_07s0005g06010, VIT_11s0016g02110, VIT_13s0158g00320, VIT_18s0001g13200, zeatin oxidase, ZmCKO1, ZmCKX1

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.12 cytokinin dehydrogenase

Engineering

Engineering on EC 1.5.99.12 - cytokinin dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E381A
the mutation mimics the active site composition of naturally occurring isozymes CKO4/6 and CKO2/3
E381S
the mutation mimics the active site composition of naturally occurring isozymes CKO4/6 and CKO2/3
L492A
the mutant retains an unchanged pattern of selectivity to variously substituted ureas but it is much more susceptible to the inhibition by phenylureas as IC50 values are 10-50times lower than those for wild type enzyme
additional information