1.5.8.3: sarcosine dehydrogenase
This is an abbreviated version!
For detailed information about sarcosine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.3
-
1.5.8.3
-
dimethylglycine
-
sarcosinemia
-
folate-binding
-
dmgdh
-
l-pipecolic
-
pipox
-
medicine
- 1.5.8.3
- dimethylglycine
-
sarcosinemia
-
folate-binding
- dmgdh
-
l-pipecolic
- pipox
- medicine
Reaction
Synonyms
EC 1.5.99.1, monomethylglycine dehydrogenase, sarcosine N-demethylase, sarcosine:(acceptor) oxidoreductase (demethylating), sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating), SARDH, SDH
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Reference on EC 1.5.8.3 - sarcosine dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tsuru, D.; Oka, I.; Yoshimoto, T.
Creatinine decomposing enzymes in Pseudomonas putida
Agric. Biol. Chem.
40
1011-1018
1976
Pseudomonas putida
-
Yamada, H.; Shimizu, S.; Kim, J.M.; Shinmen, Y.; Sakai, T.
A novel metabolic pathway for creatinine degradation in Pseudomonas putida 77
FEMS Microbiol. Lett.
30
337-340
1985
Pseudomonas putida
-
Bater, A.J.; Venables, W.A.
The characterisation of inducible dehydrogenases specific for the oxidation of D-alanine, allohydroxy-D-proline, choline and sarcosine as peripheral membrane proteins in Pseudomonas aeruginosa
Biochim. Biophys. Acta
468
209-226
1977
Pseudomonas aeruginosa, Pseudomonas reptilivorous
Smith, L.T.; Pocard, J.A.; Bernard, T.; LeRudulier, D.
Osmotic control of glycine betaine biosynthesis and degradation in Rhizobium meliloti
J. Bacteriol.
170
3142-3149
1988
Sinorhizobium meliloti
Cook, R.J.; Wagner, C.
Dimethylglycine dehydrogenase and sarcosine dehydrogenase: mitochondrial folate-binding proteins from rat liver
Methods Enzymol.
122
255-260
1986
Rattus norvegicus
Porter, D.H.; Cook, R.J.; Wagner, C.
Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver
Arch. Biochem. Biophys.
243
396-407
1985
Rattus norvegicus
Cook, R.J.; Misono, K.S.; Wagner, C.
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria
J. Biol. Chem.
260
12998-13002
1985
Rattus norvegicus
Steenkamp, D.J.; Husain, M.
The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases
Biochem. J.
203
707-715
1982
Sus scrofa
Wittwer, A.J.; Wagner, C.
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins
J. Biol. Chem.
256
4109-4115
1981
Rattus norvegicus
Wittwer, A.J.; Wagner, C.
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics
J. Biol. Chem.
256
4102-4108
1981
Rattus norvegicus
Cook, R.J.; Misono, K.S.; Wagner, C.
Identification of the covalently bound flavin of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria
J. Biol. Chem.
259
12475-12480
1980
Rattus norvegicus
Oka, I.; Yoshimoto, T.; Rikitake, K.; Ogushi, S.; Tsur, D.
Sarcosine dehydrogenase from Pseudomonas putida: purification and some properties
Agric. Biol. Chem.
43
1197-1203
1979
Corynebacterium sp., Pseudomonas putida
-
Pinto, J.T.; Frisell, W.R.
Characterization of the peptide-bound flavin of a bacterial sarcosine dehydrogenase
Arch. Biochem. Biophys.
169
483-491
1975
Pseudomonas sp.
Patek, D.R.; Frisell, W.R.
Purification and characterization of the flavin prosthetic group of sarcosine dehydrogenase
Arch. Biochem. Biophys.
150
347-354
1972
Rattus norvegicus
Frisell, W.R.; Mackenzie, C.G.
Sarcosine dehydrogenase and dimethylglycine dehydrogenase (rat liver, monkey liver)
Methods Enzymol.
17A
976-981
1970
Macaca mulatta, Rattus norvegicus
-
Frisell, W.R.; Mackenzie, C.G.
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase
J. Biol. Chem.
237
94-98
1962
Rattus norvegicus
Eschenbrenner, M.; Schuman Jorns, M.
Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia
Genomics
59
300-308
1999
Homo sapiens
Tang, T.Y.; Jong, J.G.; Liu, W.H.
Purification and some properties of sarcosine dehydrogenase from Pseudomonas putida RS65
Food Sci. Agric. Chem.
3
36-41
2001
Pseudomonas putida, Pseudomonas putida RS65
Bergeron, F.; Otto, A.; Blache, P.; Day, R.; Denoroy, L.; Brandsch, R.; Bataille, D.
Molecular cloning and tissue distribution of rat sarcosine dehydrogenase
Eur. J. Biochem.
257
556-561
1998
Rattus norvegicus
Kato, K.; Walde, P.; Mitsui, H.; Higashi, N.
Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles
Biotechnol. Bioeng.
84
415-423
2003
Pseudomonas putida
Chen, X.; Overcash, R.; Green, T.; Hoffman, D.; Asch, A.S.; Ruiz-Echevarria, M.J.
The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels
J. Biol. Chem.
286
16091-16100
2011
Homo sapiens
Umair, S.; Ria, C.; Knight, J.S.; Bland, R.J.; Simpson, H.V.
Sarcosine metabolism in Haemonchus contortus and Teladorsagia circumcincta
Exp. Parasitol.
134
1-6
2013
no activity in Haemonchus contortus, no activity in Teladorsagia circumcincta
Kim, H.; Lee, Y.; Koo, J.
Expression of sarcosine-metabolizing enzymes in thyroid cancer
Int. J. Clin. Exp. Pathol.
9
7132-7139
2016
Homo sapiens
-
Heger, Z.; Merlos Rodrigo, M.A.; Michalek, P.; Polanska, H.; Masarik, M.; Vit, V.; Plevova, M.; Pacik, D.; Eckschlager, T.; Stiborova, M.; Adam, V.
Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer
PLoS ONE
11
e0165830
2016
Homo sapiens
Green, T.; Chen, X.; Ryan, S.; Asch, A.S.; Ruiz-Echevarria, M.J.
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells
Prostate
73
1561-1575
2013
Homo sapiens
Mazdak, M.; Tezval, H.; Callauch, J.C.; Dubrowinskaja, N.; Peters, I.; Bokemeyer, C.; Hennenlotter, J.; Stenzl, A.; Kuczyk, M.A.; Serth, J.
DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma
Oncol. Rep.
42
2159-2168
2019
Homo sapiens (Q9UL12), Homo sapiens
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