1.5.7.3: N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)

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For detailed information about N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin), go to the full flat file.

Reaction

+ 2 oxidized ferredoxin +

+ 2 reduced ferredoxin + 2 H+

Synonyms

Csal_0990, DdhC, DgcA, PA5398

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.7 With an iron-sulfur protein as acceptor

1.5.7.3 N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)

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1	AA Sequence
1	Cloned(Commentary)
3	Cofactor
1	Expression
4	General Information
1	Inhibitors
2	KM Value [mM]
1	Localization
2	Metals/Ions
5	Organism
3	Pathway
1	pH Optimum
1	pH Range
1	Purification (Commentary)
2	Reaction
4	Reference
4	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
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1	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.5.7.3 - N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)

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N,N-dimethylglycine/sarcosine:ferredoxin oxidoreductase (demethylating)

This bacterial enzyme is involved in degradation of glycine betaine. The enzyme contains non-covalently bound FAD and NAD(P) cofactors, and catalyses the demethylation of both N,N-dimethylglycine and sarcosine, releasing formaldehyde and forming glycine as the final product. The enzyme can utilize both NAD+ and NADP+, but the catalytic efficiency with NAD+ is ~5-fold higher. The native electron acceptor of the enzyme is a membrane-bound clostridial-type ferredoxin, which transfers the electrons to an electron-transfer flavoprotein (ETF).