1.5.7.1: methylenetetrahydrofolate reductase (ferredoxin)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase (ferredoxin), go to the full flat file.

Reaction

+ 2 H+

Synonyms

5,10-methylenetetrahydrofolate reductase, Fdred:methylene-THF oxidoreductase, metF, methylene-H4F reductase, methylene-tetrahydrofolate reductase, methylenetetrahydrofolate reductase, MetVF-type methylenetetrahydrofolate reductase, MetVF-type MTHFR, MTHFR

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.7 With an iron-sulfur protein as acceptor

1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)

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Results	in table
1	Activating Compound
1	CAS Registry Number
1	Cloned(Commentary)
6	Cofactor
3	General Information
1	Inhibitors
4	KM Value [mM]
3	Localization
5	Metals/Ions
5	Molecular Weight [Da]
4	Organism
1	Oxidation Stability
5	Pathway
3	pH Optimum
2	pH Stability
3	Purification (Commentary)
1	Reaction
4	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
14	Substrates and Products (Substrate)
4	Subunits
14	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Reference

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Reference on EC 1.5.7.1 - methylenetetrahydrofolate reductase (ferredoxin)

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437714

Clark, J.E.; Ljungdahl, L.G.

Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum

J. Biol. Chem.

259

10845-10849

1984

Clostridium formicaceticum

6381490

742782

Mock, J.; Wang, S.; Huang, H.; Kahnt, J.; Thauer, R.K.

Evidence for a hexaheteromeric methylenetetrahydrofolate reductase in Moorella thermoacetica

J. Bacteriol.

196

3303-3314

2014

Moorella thermoacetica, Moorella thermoacetica DSM 521

25002540

764936

Oeppinger, C.; Kremp, F.; Mueller, V.

Is reduced ferredoxin the physiological electron donor for MetVF-type methylenetetrahydrofolate reductases in acetogenesis? a hypothesis

Int. Microbiol.

75-88

2021

Clostridium ljungdahlii

34255221