1.5.5.3: hydroxyproline dehydrogenase

This is an abbreviated version!
For detailed information about hydroxyproline dehydrogenase, go to the full flat file.

Word Map on EC 1.5.5.3

1.5.5.3

oxalate

glycolate

urinary

hyperoxalurias

glyoxylate

stone

prodh2

collagen

aminotransferase

dehydratase

aldolase

inborn

infancy

hyperprolinemia

delta-1-pyrroline-5-carboxylate

schizophrenia

grhpr

medicine

Reaction

(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate

Synonyms

HPOX, hydroxyproline oxidase, HYPDH, OH-POX, ProDH2, proline dehydrogenase 2

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.5 With a quinone or similar compound as acceptor

1.5.5.3 hydroxyproline dehydrogenase

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5	AA Sequence
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3	Expression
3	General Information
3	IC50 Value
5	Inhibitors
5	kcat/KM [mM/s]
1	Ki Value [mM]
4	KM Value [mM]
3	Localization
5	Natural Substrates/ Products (Substrates)
7	Organism
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1	Purification (Commentary)
1	Reaction
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10	Source Tissue
13	Substrates and Products (Substrate)
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Reference on EC 1.5.5.3 - hydroxyproline dehydrogenase

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741620

Wu, Z.; Hou, Y.; Dai, Z.; Hu, C.A.; Wu, G.

Metabolism, nutrition, and redox signaling of hydroxyproline

Antioxid. Redox Signal.

674-682

2017

Homo sapiens

28934858

741855

Summitt, C.B.; Johnson, L.C.; Joensson, T.J.; Parsonage, D.; Holmes, R.P.; Lowther, W.T.

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

Biochem. J.

466

273-281

2015

Homo sapiens (Q9UF12), Homo sapiens

25697095

741999

Li, X.; Knight, J.; Fargue, S.; Buchalski, B.; Guan, Z.; Inscho, E.W.; Liebow, A.; Fitzgerald, K.; Querbes, W.; Todd Lowther, W.; Holmes, R.P.

Metabolism of (13)C5-hydroxyproline in mouse models of primary hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase

Biochim. Biophys. Acta

1862

233-239

2016

Mus musculus

26655602

742315

Carnie, J.A.; Rowsell, E.V.; Dabbaghian, M.K.; Hobbs, D.R.; Rowsell, K.V.

Comparative and developmental studies on 4-hydroxy-2-oxoglutarate aldolase and hydroxyproline oxidase

Comp. Biochem. Physiol. B

681-687

1982

Rattus norvegicus

7083820

742832

Cooper, S.K.; Pandhare, J.; Donald, S.P.; Phang, J.M.

A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species

J. Biol. Chem.

283

10485-10492

2008

Homo sapiens (Q9UF12)

18287100

743217

Lowry, M.; Hall, D.E.; Brosnan, J.T.

Hydroxyproline metabolism by the rat kidney distribution of renal enzymes of hydroxyproline catabolism and renal conversion of hydroxyproline to glycine and serine

Metab. Clin. Exp.

955-961

1985

Rattus norvegicus

3930916

764206

Buchalski, B.; Wood, K.D.; Challa, A.; Fargue, S.; Holmes, R.P.; Lowther, W.T.; Knight, J.

The effects of the inactivation of hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria

Biochim. Biophys. Acta

1866

165633

2020

Mus musculus (Q8VCZ9), Mus musculus

31821850