1.5.5.3: hydroxyproline dehydrogenase
This is an abbreviated version!
For detailed information about hydroxyproline dehydrogenase, go to the full flat file.
Word Map on EC 1.5.5.3
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1.5.5.3
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oxalate
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glycolate
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urinary
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hyperoxalurias
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glyoxylate
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stone
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prodh2
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collagen
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aminotransferase
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dehydratase
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aldolase
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inborn
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infancy
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hyperprolinemia
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delta-1-pyrroline-5-carboxylate
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schizophrenia
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grhpr
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medicine
- 1.5.5.3
- oxalate
- glycolate
- urinary
- hyperoxalurias
- glyoxylate
-
stone
- prodh2
- collagen
- aminotransferase
- dehydratase
- aldolase
-
inborn
-
infancy
-
hyperprolinemia
-
delta-1-pyrroline-5-carboxylate
-
schizophrenia
- grhpr
- medicine
Reaction
Synonyms
HPOX, hydroxyproline oxidase, HYPDH, OH-POX, ProDH2, proline dehydrogenase 2
ECTree
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Application
Application on EC 1.5.5.3 - hydroxyproline dehydrogenase
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medicine
the enzyme is a therapeutic target for the treatment of primary hyperoxaluria
medicine
creation of a ProDH2 knock out mouse model. The lack of hydroxyproline dehydrogenase in primary hyperoxalurias mouse models results in lower levels of urinary oxalate excretion. In the double knockout mouse, lacking both glyoxylate reductase/hydroxypyruvate reductase Grhpr and ProDH2, calcium-oxalate crystal deposition in the kidney is prevented, when placed on a 1% hydroxyproline diet