1.5.3.25: fructosyl amine oxidase (glucosone-forming)

This is an abbreviated version!
For detailed information about fructosyl amine oxidase (glucosone-forming), go to the full flat file.

Reaction

Synonyms

AgaE-like protein, amadoriase, amadoriase I, amadoriase II, FaoA, FAOAo1, FAOAo2, FAOD, FAOD-Ao1, FAOD-Ao2, FAOX, FAOX-C, FAOX-II, FrlB, fructosyl amine:oxygen oxidoreductase, fructosyl amino acid oxidase, GAOA

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.3 With oxygen as acceptor

                1.5.3.25 fructosyl amine oxidase (glucosone-forming)

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Results	in table
11	AA Sequence
2	Application
10	Cloned(Commentary)
6	Cofactor
6	Crystallization (Commentary)
2	Expression
4	General Information
7	Inhibitors
66	kcat/KM [mM/s]
100	KM Value [mM]
2	Localization
3	Metals/Ions
6	Molecular Weight [Da]
34	Organism
8	pH Optimum
3	pI Value
57	Protein Variants
2	Purification (Commentary)
3	Reaction
33	Reference
2	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
11	Subunits
22	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
75	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.5.3.25 - fructosyl amine oxidase (glucosone-forming)

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SYSTEMATIC NAME

IUBMB Comments

N-(1-deoxy-D-fructos-1-yl)amine:oxygen 2-oxidoreductase (glucosone-forming)

Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound. These reactions are known as glycation reactions, and the stable products are known as Amadori products. This enzyme, which contains an FAD cofactor, catalyses a deglycation reaction that regenerates the amine reactant. By-products are glucosone and hydrogen peroxide. The enzymes have been reported from fungi and bacteria, but not from higher eukaryotes. Specific enzymes differ in their substrate specificity. cf. EC 1.5.3.26, fructosyl amine oxidase (fructosamine-forming).