1.5.3.2: N-methyl-L-amino-acid oxidase

This is an abbreviated version!
For detailed information about N-methyl-L-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.5.3.2

Reaction

an N-methyl-L-amino acid
+
H2O
+
O2
=
an L-amino acid
+
formaldehyde
+
H2O2

Synonyms

demethylase, N-methylamino acid oxidase, oxidase, N-methylamino acid

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.2 N-methyl-L-amino-acid oxidase

Substrates Products

Substrates Products on EC 1.5.3.2 - N-methyl-L-amino-acid oxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-N-methyl-L-histidine + O2 + H2O
L-histidine + formaldehyde + H2O2
show the reaction diagram
-
-
-
-
?
alpha-N-methyl-L-tryptophan + O2 + H2O
L-tryptophan + formaldehyde + H2O2
show the reaction diagram
-
alpha-N-methyl-L-tryptophan is identical with L-abrine
-
?
N-methyl-L-amino acid + O2 + H2O
L-amino acid + formaldehyde + H2O2
show the reaction diagram
-
enzyme requires the presence of a free alpha-carboxyl group in the substrate molecule, substrates with aromatic or heterocyclic substituents are more readily oxidized, followed by aliphatic N-methylamino acids with long side chain, more slowly activity towards N-methyl derivatives of beta-hydroxy-amino acids and of basic and acidic amino acids with exception of histidin, very slow demethylation of phenylsarcosine
-
?
N-methyl-L-norleucine + O2 + H2O
L-norleucine + formaldehyde + H2O2
show the reaction diagram
-
-
-
?
N-methyl-L-phenylalanine + O2 + H2O
L-phenylalanine + formaldehyde + H2O2
show the reaction diagram
-
-
-
-
?
N-methyl-L-tyrosine + O2 + H2O
L-tyrosine + formaldehyde + H2O2
show the reaction diagram
-
N-methyl-DL-tyrosine is identical with surinamine
-
-
?
N-methyldihydroxyphenyl-DL-alanine + O2 + H2O
formaldehyde + dihydroxyphenyl-DL-alanine + H2O2
show the reaction diagram
-
-
-
-
?
N-methylvanillyl-L-alanine + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
more substrates, not with: N-dimethyl-L-amino acid, N-methyl-D-amino acid, L-amino acid, D-amino acid
-
-
-