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1.5.3.13: N1-acetylpolyamine oxidase

This is an abbreviated version!
For detailed information about N1-acetylpolyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.13

Reaction

N1-acetylspermidine
+
O2
 +
H2O
=
putrescine
 +
3-acetamidopropanal
 +
H2O2

Synonyms

APAO, AtPAO5, Bjpao2, EC 1.5.3.11, HPAO, hPAO-1, More, MPAO, N1-acetyl polyamine oxidase, N1-acetylpolyamine oxidase, PAO, PAO5, PAOh1, PAOX, polyamine oxidase, SelPAO5

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.13 N1-acetylpolyamine oxidase

Turnover Number

Turnover Number on EC 1.5.3.13 - N1-acetylpolyamine oxidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0052
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide
pH 9, 25°C
-
0.00001
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide
pH 9, 25°C
-
0.415
N1,N11-bis(ethyl)-norspermine
pH 7.6, 30°C
19
N1,N11-diacetylnorspermine
-
-
1.93
N1,N12-bis(ethyl)-spermine
pH 7.6, 30°C
2.7 - 15
N1-acetylspermidine
0.025 - 31.7
N1-acetylspermine
4.6
N1-benzoyl-(R)-alpha-methylspermidine
pH 9, 25°C
-
0.03
N1-benzoyl-(S)-alpha-methylspermidine
pH 9, 25°C
-
0.00003 - 0.00014
N1-phenyl-(R)-alpha-methylspermidine
-
0.0004 - 8.8
spermine
additional information
additional information
-
kinetic characteristics of the degradation of spermidine, racemic, and different isomers of alpha-methylspermidine by human polyamine oxidase in the presence of different aldehydes. Kinetic values of spermine and different diastereomers of bis-alpha,alpha'-methylspermine for human polyamine oxidase in the presence of different aldehydes
-