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1.5.3.13: N1-acetylpolyamine oxidase

This is an abbreviated version!
For detailed information about N1-acetylpolyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.13

Reaction

N1-acetylspermidine
+
O2
 +
H2O
=
putrescine
 +
3-acetamidopropanal
 +
H2O2

Synonyms

APAO, AtPAO5, Bjpao2, EC 1.5.3.11, HPAO, hPAO-1, More, MPAO, N1-acetyl polyamine oxidase, N1-acetylpolyamine oxidase, PAO, PAO5, PAOh1, PAOX, polyamine oxidase, SelPAO5

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.13 N1-acetylpolyamine oxidase

Systematic Name

Systematic Name on EC 1.5.3.13 - N1-acetylpolyamine oxidase

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SYSTEMATIC NAME
IUBMB Comments
N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming)
The enzyme also catalyses the reaction: N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamamidopropanal + H2O2 [1]. No or very weak activity with spermine, or spermidine in absence of aldehydes. In presence of aldehydes the enzyme catalyses the reactions: 1. spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2, and with weak efficiency 2. spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [2]. A flavoprotein (FAD). This enzyme, encoded by the PAOX gene, is found in mammalian peroxisomes and oxidizes N1-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal. Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion. Differs in specificity from EC 1.5.3.14 [polyamine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.15 [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase).