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1.5.3.13: N1-acetylpolyamine oxidase

This is an abbreviated version!
For detailed information about N1-acetylpolyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.13

Reaction

N1-acetylspermidine
+
O2
+
H2O
=
putrescine
+
3-acetamidopropanal
+
H2O2

Synonyms

APAO, AtPAO5, Bjpao2, EC 1.5.3.11, HPAO, hPAO-1, More, MPAO, N1-acetyl polyamine oxidase, N1-acetylpolyamine oxidase, PAO, PAO5, PAOh1, PAOX, polyamine oxidase, SelPAO5

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.13 N1-acetylpolyamine oxidase

Substrates Products

Substrates Products on EC 1.5.3.13 - N1-acetylpolyamine oxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-alpha-methylspermidine + O2 + H2O
?
show the reaction diagram
-
PAO supplemented with benzaldehyde predominantly catalyzes the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine is preferred
-
-
?
(S)-alpha-methylspermidine + O2 + H2O
?
show the reaction diagram
-
PAO supplemented with benzaldehyde predominantly catalyzes the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine is preferred
-
-
?
(S)-N1-(2-methyl-1-butyl)-N11-ethyl-4,8-diazaundecane-1,11-diamine + O2 + H2O
?
show the reaction diagram
-
-
-
?
1-amino-8-acetamido-5-azanonane + O2 + H2O
?
show the reaction diagram
-
less preferred substrate
-
-
?
3-[4-(3-aminopropoxy)butoxy]-N-benzylpropan-1-amine + O2 + H2O
?
show the reaction diagram
-
-
-
?
alpha-methylspermidine + O2 + H2O
?
show the reaction diagram
-
weak oxidation in presence of benzaldehyde, no oxidation without benzaldehyde
-
-
?
alpha-methylspermine + O2 + H2O
?
show the reaction diagram
-
oxidation in presence of benzaldehyde, no oxidation without benzaldehyde
-
-
?
alpha-methylspermine + O2 + H2O
spermidine + alpha-methylspermidine + ?
show the reaction diagram
-
-
-
-
?
bis-alpha,alpha'-methylspermine + O2 + H2O
alpha-methylspermidine + ?
show the reaction diagram
-
-
-
-
?
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
N1-(3-benzylaminopropyl)butane-1,4-diamine + H2O2 + ?
show the reaction diagram
-
-
main product
-
?
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
N1-(3-benzylaminopropyl)butane-1,4-diamine + N-(3-aminopropyl)-N'-(3-Benzylaminopropyl)butane-1,4-diamine + H2O2
show the reaction diagram
-
-
-
-
?
N,N'-bis-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O
N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ?
show the reaction diagram
-
minor N4-endo cleavage pathways resulting in formation of N1-ethylpropane-1,3-diamine
-
-
?
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O
N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ?
show the reaction diagram
-
-
-
-
?
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide + O2 + H2O
putrescine + (3R)-3-[(pyridin-4-yl)amino]butanal + H2O2
show the reaction diagram
-
-
-
?
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide + O2 + H2O
putrescine + (3S)-3-[(pyridin-4-yl)amino]butanal + H2O2
show the reaction diagram
-
-
-
?
N1,N11-bis(ethyl)-norspermine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1,N11-diacetylnorspermine + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
N1,N11-didansylnorspermine + O2 + H2O
1-dansylnorspermidine + 1-dansylamido-3-propanal + H2O2
show the reaction diagram
N1,N11-didansylnorspermine + O2 + H2O
? + H2O2
show the reaction diagram
-
-
-
-
?
N1,N11-diethylnorspermine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1,N12-bis(ethyl)-spermine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1,N12-bisethylspermine + H2O
?
show the reaction diagram
mechanistic studies
-
-
?
N1,N12-diacetylspermine + O2 + H2O
?
show the reaction diagram
N1,N12-diacetylspermine + O2 + H2O
N1-acetylspermidine + 3-acetamidopropanal + H2O2
show the reaction diagram
N1,N12-diethylspermine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1,N14-diethylhomospermine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
spermidine + H2O2 + benzylalcohol
show the reaction diagram
-
-
-
-
?
N1-(3-[[(thiophen-2-yl)methyl]amino]propyl)octane-1,8-diamine + O2 + H2O
octane-1,8-diamine + N1-[(thiophen-2-yl)methyl]propanal + H2O2
show the reaction diagram
-
-
-
?
N1-acetyl-2-methylspermidine + O2 + H2O
putrescine + N-(2-methyl-3-oxopropyl)acetamide + H2O2
show the reaction diagram
-
-
-
?
N1-acetyl-8-methylspermidine + O2 + H2O
pentane-1,4-diamine + 3-acetamidopropanal + H2O2
show the reaction diagram
-
-
-
?
N1-acetylspermidine + O2 + H2O
?
show the reaction diagram
N1-acetylspermidine + O2 + H2O
putrescine + 3-acetamidopropanal
show the reaction diagram
-
-
-
?
N1-acetylspermidine + O2 + H2O
putrescine + 3-acetamidopropanal + H2O2
show the reaction diagram
N1-acetylspermidine + O2 + H2O
putrescine + 3-acetaminopropanal + H2O2
show the reaction diagram
-
-
-
?
N1-acetylspermine + O2 + H2O
?
show the reaction diagram
N1-acetylspermine + O2 + H2O
spermidine + 3-acetamidopropanal + H2O2
show the reaction diagram
N1-acetylspermine + O2 + H2O
spermidine + 3-acetaminopropanal + H2O2
show the reaction diagram
-
-
-
?
N1-benzoyl-(R)-alpha-methylspermidine + O2 + H2O
putrescine + N-[(2R)-4-oxobutan-2-yl]benzamide + H2O2
show the reaction diagram
-
-
-
?
N1-benzoyl-(S)-alpha-methylspermidine + O2 + H2O
putrescine + N-[(2S)-4-oxobutan-2-yl]benzamide + H2O2
show the reaction diagram
-
-
-
?
N1-benzyl-propane-1,3-diamine + O2 + H2O
propane-1,3-diamine + H2O2 + benzylalcohol
show the reaction diagram
-
-
-
-
?
N1-benzyldodecane-1,12-diamine + O2 + H2O
dodecane-1,12-diamine + N1-benzylpropanal + H2O2
show the reaction diagram
-
-
-
?
N1-benzylspermine + O2 + H2O
spermidine + 3-(benzylamino)propanal + H2O2
show the reaction diagram
-
-
-
?
N1-cyclopropylmethyl-N11-ethylnorspermine + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
N1-ethyl-N11-(cycloheptyl)methyl-4,8-diazaundecane-1,11-diamine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1-ethyl-N11-(cyclopropyl)methyl-4,8-diazaundecane + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1-phenyl-(R)-alpha-methylspermidine + O2 + H2O
putrescine + (3R)-3-anilinobutanal + H2O2
show the reaction diagram
-
-
-
?
N1-phenyl-(S)-alpha-methylspermidine + O2 + H2O
putrescine + (3S)-3-anilinobutanal + H2O2
show the reaction diagram
-
-
-
?
N1-[(naphthalen-2-yl)methyl]spermine + O2 + H2O
spermidine + N1-[(naphthalen-2-yl)methyl]propanal + H2O2
show the reaction diagram
-
-
-
?
N1-[(pyridin-2-yl)methyl]spermine + O2 + H2O
spermidine + N1-[(pyridin-2-yl)methyl]propanal + H2O2
show the reaction diagram
-
-
-
?
N1-[(thiophen-2-yl)methyl]dodecane-1,12-diamine + O2 + H2O
?
show the reaction diagram
-
-
-
?
N1-[(thiophen-2-yl)methyl]spermine + O2 + H2O
spermidine + N1-[(thiophen-2-yl)methyl]propanal + H2O2
show the reaction diagram
-
-
-
?
spermidine + O2 + H2O
?
show the reaction diagram
spermine + O2 + H2O
?
show the reaction diagram
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
show the reaction diagram
additional information
?
-