1.5.3.13: N1-acetylpolyamine oxidase

This is an abbreviated version!
For detailed information about N1-acetylpolyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.13

Reaction

N1-acetylspermidine
+
O2
+
H2O
=
putrescine
+
3-acetamidopropanal
+
H2O2

Synonyms

APAO, AtPAO5, Bjpao2, HPAO, hPAO-1, More, MPAO, N1-acetyl polyamine oxidase, N1-acetylpolyamine oxidase, PAO, PAO5, PAOh1, polyamine oxidase, SelPAO5

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.13 N1-acetylpolyamine oxidase

Inhibitors

Inhibitors on EC 1.5.3.13 - N1-acetylpolyamine oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,12-diaminododecane
1,12-diaminododecane derivatives could represent good candidates for the development of novel highly specific mPAO inhibitors
1,8-diaminooctane
competitive versus the polyamine
guazatine
-
MDL72527
N,N-di-2,3-butadienyl-1,4-butanediamine
-
i.e. MDL 72527, strong inhibition
N,N'-butanedienyl butanediamine
-
i.e. MDL 72527 or CPC-200, a small molecule specific inhibitor of polyamine oxidase, effectively blocks androgen-induced reactive oxygen species production in human prostate cancer cells, as well as significantly delays prostate cancer progression and death in animals developing spontaneous prostate cancer
N-(3-aminopropyl)-N-2-propenyl-1,4-butanediamine
-
moderate inhibition
N-(3-aminopropyl)-N-2,3-butadienyl-1,4-butanediamine
-
strong inhibition
N-prenylagmatine
-
N-[3-(2,3-butadienylamino)propyl]-1,4-butanediamine
-
strong inhibition
N-[3-(2-propenylamino) propyl]-1,4-butanediamine
-
moderate inhibition
N1,N4-bis(2,3-butadienyl)-1,4-butanediamine
N1-acetyl-1,12-diaminododecane
competitive versus the polyamine
N1-acetyl-1,8-diaminooctane
competitive versus the polyamine
N1-acetyl-N3-pentyl-1,3-diaminopropane
competitive versus the polyamine
N8-acetylspermine
-
putrescine
-
SL-11144
0.01 mM, 80% inhibition
SL-11150
0.01 mM, complete inhibition
SL-11158
0.01 mM, complete inhibition
spermidine
-
additional information
-