1.5.1.9: saccharopine dehydrogenase (NAD+, L-glutamate-forming)

This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NAD+, L-glutamate-forming), go to the full flat file.

Reaction

Synonyms

AasS, alpha-aminoadipic-delta-semialdehehyde synthase, aminoadipic semialdehyde synthase, AtLKR/SDHp, AtSDHp, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), LKR/SDH, LOR-SDH, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming), nllkr/sdh, saccharopin dehydrogenase, saccharopine dehydrogenase, SacD, SDH, spe-sdh

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)

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Results	in table
3	Activating Compound
151	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
48	Cofactor
4	Disease/ Diagnostics
6	Expression
18	General Information
1	General Stability
11	Inhibitors
14	KM Value [mM]
24	Localization
5	Metals/Ions
20	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
42	Organism
1	Oxidation Stability
6	Pathway
17	PDB ID
9	pH Optimum
3	pH Range
5	pH Stability
2	pI Value
3	Posttranslational Modification
13	Purification (Commentary)
1	Reaction
3	Reaction Type
39	Reference
47	Source Tissue
19	Specific Activity [micromol/min/mg]
2	Storage Stability
65	Substrates and Products (Substrate)
17	Subunits
61	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.5.1.9 - saccharopine dehydrogenase (NAD+, L-glutamate-forming)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-Glu + 2-aminoadipate 6-semialdehyde + NADH

Arabidopsis sp.

-

the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level

657056

-

-

?

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

8 entries

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

15 entries

saccharopine + NAD+ + H2O

L-glutamate + alpha-aminoadipate semialdehyde + NADH + H+

3 entries

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Arabidopsis thaliana

Q9SMZ4

reaction of the SDH domain

763097

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Brassica napus

Q9FVF4

reaction of the SDH domain

763097

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Homo sapiens

Q9UDR5

reaction of the SDH domain

763097

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Hordeum vulgare

-

-

743526

-

-

?

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Nilaparvata lugens

A0A089MUZ6

-

743575

-

-

?

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Oryza sativa

A0A0K0K9B1

reaction of the SDH domain

763097

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Triticum turgidum

D8WKY4

-

724672

-

-

?

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+

Zea mays

A0A3L6FCN0

reaction of the SDH domain

763097

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Arabidopsis thaliana

-

involved in lysine catabolism

396550

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Bos taurus

-

involved in lysine catabolism

396544

-

-

?

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Bos taurus

-

involved in lysine catabolism

392363, 392364, 392365

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Canis lupus familiaris

-

involved in lysine catabolism

392363

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Felis catus

-

involved in lysine catabolism

392363

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Glycine max

-

involved in lysine catabolism

392371

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Homo sapiens

-

involved in lysine catabolism

392361, 392363, 396540, 396543

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Oryza sativa

-

involved in lysine catabolism

392370

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Ovis aries

-

involved in lysine catabolism

392363

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Papio hamadryas

-

involved in lysine catabolism

392364

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Rattus norvegicus

-

involved in lysine catabolism

392366, 396544

-

-

?

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Rattus norvegicus

-

involved in lysine catabolism

392363

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Rattus norvegicus Wistar

-

involved in lysine catabolism

392363

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Sus scrofa

-

involved in lysine catabolism

392363

-

-

r

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

Zea mays

-

involved in lysine catabolism

396547

-

-

r

saccharopine + NAD+ + H2O

L-glutamate + alpha-aminoadipate semialdehyde + NADH + H+

Nostoc punctiforme

-

-

725019

-

-

r

saccharopine + NAD+ + H2O

L-glutamate + alpha-aminoadipate semialdehyde + NADH + H+

Nostoc punctiforme ATCC 29133

-

-

725019

-

-

r

saccharopine + NAD+ + H2O

L-glutamate + alpha-aminoadipate semialdehyde + NADH + H+

Ruegeria pomeroyi

-

-

725019

-

-

r