1.5.1.9: saccharopine dehydrogenase (NAD+, L-glutamate-forming)

This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NAD+, L-glutamate-forming), go to the full flat file.

Word Map on EC 1.5.1.9

Reaction

N6-(L-1,3-dicarboxypropyl)-L-lysine
+
NAD+
+
H2O
=
L-glutamate
+
(S)-2-amino-6-oxohexanoate
+
NADH
+
H+

Synonyms

alpha-aminoadipic-delta-semialdehehyde synthase, aminoadipic semialdehyde synthase, AtLKR/SDHp, AtSDHp, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), LKR/SDH, LOR-SDH, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming), nllkr/sdh, saccharopin dehydrogenase, saccharopine dehydrogenase, SacD, SDH, spe-sdh

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)

Natural Substrates Products

Natural Substrates Products on EC 1.5.1.9 - saccharopine dehydrogenase (NAD+, L-glutamate-forming)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-Glu + 2-aminoadipate 6-semialdehyde + NADH
show the reaction diagram
-
the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level
-
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
show the reaction diagram
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
show the reaction diagram
saccharopine + NAD+ + H2O
L-glutamate + alpha-aminoadipate semialdehyde + NADH + H+
show the reaction diagram