1.5.1.9: saccharopine dehydrogenase (NAD+, L-glutamate-forming)

This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NAD+, L-glutamate-forming), go to the full flat file.

Word Map on EC 1.5.1.9

Reaction

N6-(L-1,3-dicarboxypropyl)-L-lysine
+
NAD+
+
H2O
=
L-glutamate
+
(S)-2-amino-6-oxohexanoate
+
NADH
+
H+

Synonyms

alpha-aminoadipic-delta-semialdehehyde synthase, aminoadipic semialdehyde synthase, AtLKR/SDHp, AtSDHp, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), LKR/SDH, LOR-SDH, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming), nllkr/sdh, saccharopin dehydrogenase, saccharopine dehydrogenase, SacD, SDH, spe-sdh

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)

Molecular Weight

Molecular Weight on EC 1.5.1.9 - saccharopine dehydrogenase (NAD+, L-glutamate-forming)

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
44000
44100
48000
-
calculated from amino acid sequence
63000
-
x * 63000, SDS-PAGE, monofunctional enzyme
115000
120000
-
x * 120000, SDS-PAGE, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein
125000
-
2 * 125000, SDS-PAGE, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein
190000
-
bifunctional enzyme lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, gel filtration
202000
-
native non-denaturing gel, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein
203000
-
gel filtration with Sephacryl S-200, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein
260000
-
gel filtration with Superdex, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein
396000
-
native non-denaturing gel, low activity compared to 202000 kDa band
420000
-
sedimentation equilibrium method
467000
-
gel filtration, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase
468000
-
gel filtration, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase
480000
-
gel filtration