1.5.1.9: saccharopine dehydrogenase (NAD+, L-glutamate-forming)

This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NAD+, L-glutamate-forming), go to the full flat file.

Word Map on EC 1.5.1.9

Reaction

N6-(L-1,3-dicarboxypropyl)-L-lysine
+
NAD+
+
H2O
=
L-glutamate
+
(S)-2-amino-6-oxohexanoate
+
NADH
+
H+

Synonyms

alpha-aminoadipic-delta-semialdehehyde synthase, aminoadipic semialdehyde synthase, AtLKR/SDHp, AtSDHp, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), LKR/SDH, LOR-SDH, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming), nllkr/sdh, saccharopin dehydrogenase, saccharopine dehydrogenase, SacD, SDH, spe-sdh

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)

Inhibitors

Inhibitors on EC 1.5.1.9 - saccharopine dehydrogenase (NAD+, L-glutamate-forming)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Aminoadipate
-
strong inhibition at 5 mM
2-oxoglutarate
-
-
3-acetylpyridine-NAD
-
15% inhibition
3-pyridine aldehyde-NAD
-
40% inhibition
hydroxylamine
-
slight
L-glutamate
-
-
NH4Cl
-
slight
p-hydroxymercuribenzoate
-
-
Sodium bisulfite
-
slight
additional information
-