1.5.1.7: saccharopine dehydrogenase (NAD+, L-lysine-forming)
This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NAD+, L-lysine-forming), go to the full flat file.
Reaction
+
+
=
+
+
+
Synonyms
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), Fvsdh, LYS1, Lys1p, Lysine--2-oxoglutarate reductase, lysine-2-oxoglutarate reductase, N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine: NAD oxidoreductase, N6-(glutaryl-2)-L-lysine: NAD+ oxidoreductase, N6-(glutaryl-2)-l-lysine:NAD oxidoreductase, N6-(glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), N6-(glutaryl-2)-L-lysine:NAD-oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine:nicotinamide adenine dinucleotide (NAD+) oxidoreductase (L-lysine-forming), NAD+-linked saccharopine dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (L-lysine-forming), SDH
ECTree
KI Value
KI Value on EC 1.5.1.7 - saccharopine dehydrogenase (NAD+, L-lysine-forming)
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1.5
2',3'-cyclic NADP
-
at pH 7.0
0.42
adenosine
-
at pH 7.0
0.29
ADP-ribose
-
at pH 7.0
5.3
alpha-ketoadipate
-
at pH 7.0
0.6 - 28
alpha-ketoglutarate
36
alpha-ketoisovalerate
-
at pH 7.0
24
alpha-ketomalonate
-
at pH 7.0
18
alpha-ketopimelate
-
at pH 7.0
16.4
L-arginine
-
at pH 7.0
16
L-glutamine
-
at pH 7.0
22
L-isoleucine
-
at pH 7.0
3.12
L-methionine
-
at pH 7.0
1.13
L-norvaline
-
at pH 7.0
5
L-ornithine
-
at pH 7.0
6.4
oxaloacetate
-
at pH 7.0
0.1
oxalylglycine
-
at pH 7.0
18.3
pyridine 2,3-dicarboxylate
-
at pH 7.0
1.1
Pyridine 2,4-dicarboxylate
-
at pH 7.0
additional information
additional information
-
inhibition studies with substrates analogues
-
0.6
alpha-ketoglutarate
-
at pH 7.0
28
alpha-ketoglutarate
-
25°C, pH 7.0
0.125
L-leucine
-
at pH 6.0
5.6
L-leucine
-
at pH 7.0
1.1
L-lysine
-
at pH 7.0
27.8
L-lysine
-
25°C, pH 7.0
0.5
NAD+
-
mutant E78Q, 25°C, pH 7.2
1.1
NAD+
-
wild-type, 25°C, pH 7.2
1.1
NAD+
-
wild type enzyme, at pH 7.0 and 25°C
1.4
NAD+
-
mutant enzyme C205S, at pH 7.0 and 25°C
1.5
NAD+
-
mutant enzyme C205V, at pH 7.0 and 25°C
1.9
NAD+
-
mutant E122Q, 25°C, pH 7.2
0.015
NADH
-
mutant E78A/E122A, 25°C, pH 7.2
0.017
NADH
-
wild-type, 25°C, pH 7.2
0.019
NADH
-
mutant E122A, 25°C, pH 7.2
0.038
NADH
-
mutant E78A, 25°C, pH 7.2