1.5.1.7: saccharopine dehydrogenase (NAD+, L-lysine-forming)

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For detailed information about saccharopine dehydrogenase (NAD+, L-lysine-forming), go to the full flat file.

Reaction

Synonyms

dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), Fvsdh, LYS1, Lys1p, Lysine--2-oxoglutarate reductase, lysine-2-oxoglutarate reductase, N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine: NAD oxidoreductase, N6-(glutaryl-2)-L-lysine: NAD+ oxidoreductase, N6-(glutaryl-2)-l-lysine:NAD oxidoreductase, N6-(glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), N6-(glutaryl-2)-L-lysine:NAD-oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine:nicotinamide adenine dinucleotide (NAD+) oxidoreductase (L-lysine-forming), NAD+-linked saccharopine dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (L-lysine-forming), SDH

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.7 saccharopine dehydrogenase (NAD+, L-lysine-forming)

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Results	in table
3898	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
37	Cofactor
3	Crystallization (Commentary)
9	General Information
7	General Stability
87	Inhibitors
48	Ki Value [mM]
79	KM Value [mM]
2	Localization
5	Metals/Ions
7	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
38	Organism
7	Pathway
13	PDB ID
10	pH Optimum
2	pH Range
1	pH Stability
17	Protein Variants
10	Purification (Commentary)
7	Reaction
5	Reaction Type
36	Reference
8	Source Tissue
12	Specific Activity [micromol/min/mg]
3	Storage Stability
44	Substrates and Products (Substrate)
2	Subunits
33	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Turnover Number [1/s]

Cloned

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Cloned on EC 1.5.1.7 - saccharopine dehydrogenase (NAD+, L-lysine-forming)

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expressed in Escherichia coli B834(DE3) cells

Saccharomyces cerevisiae

P38998

688383

expressed in Escherichia coli BL21 (DE3)-RIL cells

2 entries

expressed in Escherichia coli BL21(DE3)-RIL cells

Saccharomyces cerevisiae

724117

gene Fvsdh, cloned from genomic DNA, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree

Flammulina velutipes

A0A4Y5PV56

765014

gene LYS1, recombinant expression of GFP-tagged Lys1p in glucose-grown cells, it colocalizes with the peroxisomal marker HcRed-PTS1, recombinant expression of the enzyme in mdh3/gpd1DELTA cells and mislocation to the cytosol

Saccharomyces cerevisiae

P38998

765801