1.5.1.6: formyltetrahydrofolate dehydrogenase

This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.

Word Map on EC 1.5.1.6

1.5.1.6

one-carbon

folate-dependent

10-formyl-thf

nadp+-independent

aldh1b1

medicine

mthfd2

Reaction

Synonyms

10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.6 formyltetrahydrofolate dehydrogenase

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Results	in table
10	Activating Compound
1971	AA Sequence
6	Application
1	CAS Registry Number
20	Cloned(Commentary)
102	Cofactor
2	Crystallization (Commentary)
195	Disease/ Diagnostics
1	General Information
2	General Stability
36	Inhibitors
6	Ki Value [mM]
24	KM Value [mM]
24	Localization
30	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
45	Organism
1	Oxidation Stability
2	Pathway
43	PDB ID
5	pH Optimum
1	pH Range
2	pI Value
5	Posttranslational Modification
27	Protein Variants
28	Purification (Commentary)
5	Reaction
5	Reaction Type
44	Reference
74	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
107	Substrates and Products (Substrate)
23	Subunits
38	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
5	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase

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0.00278

Mus musculus

liver samples enriched for cytosolic proteins, heterozygous mice with deletion mutation in the FDH structural gene

392354

0.00478

Mus musculus

liver samples enriched for cytosolic proteins, normal mice

392354

0.094

Rattus norvegicus

recombinant FDH, 10-formyltetrahydrofolate as substrate

392352

0.144

Rattus norvegicus

with 10-formyl-5,8-dideazafolate as substrate

392351

0.26

Rattus norvegicus

with 10-formyltetrahydrofolate as substrate

0.305

0.347

0.51

0.64

0.7 - 0.8

at 25°C

0.98

1.04

30°C, pH not specified in the publication, recombinant enzyme expressed in Pichia pastoris

713460

additional information

5 entries