1.5.1.6: formyltetrahydrofolate dehydrogenase
This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.
Reaction
Synonyms
10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I
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medicine
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formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels
medicine
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methanol-induced toxicity in Müller cells of the retina, role of 10-FDH in formate intoxination both as a protectant and as a toxicity-provoking element
medicine
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enzyme-induced suppressor effects are strictly dependent on p53 tumor suppressor protein in A549 cells. Enzyme elevation results in p53 phosphorylation at S6 and S20 in the p53 transactivation domain, and S392 in the C-terminal domain, but only S6 is strictly required to mediate enzyme effects
medicine
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feeding of ethanol decreases hepatic enzyme activity, decrease occurs irrespective of folate status