1.5.1.50: dihydromonapterin reductase
This is an abbreviated version!
For detailed information about dihydromonapterin reductase, go to the full flat file.
Reaction
Synonyms
FolM, H2-MPt reductase, More, PA3437, pteridine reductase, PTR1, ydgB
ECTree
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Substrates Products on EC 1.5.1.50 - dihydromonapterin reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-hydroxymethyldihydropterin + NADPH + H+
? + NADP+
weak activity
-
-
?
7,8-dihydroneopterin + NADPH + H+
5,6,7,8-tetrahydroneopterin + NADP+
stereoisomer of biopterin, high activity
-
-
?
dihydromonapterin + NADPH + H+
tetrahydromonapterin + NADP+
best substrate
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
low activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
high activity
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
-
activity of dihydrofolate reductase, EC 1.5.1.3. Activity with 7,8-dihydromonapterin is 16fold higher than that with 7,8-dihydrofolate
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
moderate activity
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
best substrate
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromoapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
-
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
7,8-dihydromonapterin + NADPH + H+
5,6,7,8-tetrahydromonapterin + NADP+
high activity
-
-
?
additional information
?
-
isoform FolM possesses weak dihydrofolate reductase activity, EC 1.5.1.3
-
-
?
additional information
?
-
no substrate: folic acid, biopterin. Enzyme is able to reduce dihydrofolate, EC 1.5.1.3
-
-
?
additional information
?
-
no substrates: quinonoid form of dihydromonapterin, monapterin, dihydroneopterin
-
-
?
additional information
?
-
-
no substrates: quinonoid form of dihydromonapterin, monapterin, dihydroneopterin
-
-
?
additional information
?
-
although presumably not its primary physiological functions, this SDR pteridine reductase also exhibits dihydrofolate reductase (DHFR) activity in vitro. Substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
additional information
?
-
substrate specificity, overview. No activity with biopterin and folate
-
-
-
